Percutaneous Epicardial Pacing Using a Novel Insulated Multi-Electrode Lead

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F15%3A00085403" target="_blank" >RIV/00216224:14110/15:00085403 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00159816:_____/15:00063409

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.jacep.2015.04.012" target="_blank" >http://dx.doi.org/10.1016/j.jacep.2015.04.012</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jacep.2015.04.012" target="_blank" >10.1016/j.jacep.2015.04.012</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Percutaneous Epicardial Pacing Using a Novel Insulated Multi-Electrode Lead

Popis výsledku v původním jazyce

Objectives This study hypothesized that shielded electrodes could capture myocardium without extracardiac stimulation. Background Epicardial cardiac resynchronization therapy (CRT) permits unrestricted electrode positioning. However, this therapy requires surgical placement of device leads and risks unwanted phrenic nerve stimulation. Methods In 6 dog and 5 swine experiments, we used a percutaneous approach to access the epicardial surface of the heart and deployed novel leads housing multiple electrodes with selective insulation. Bipolar pacing thresholds at pre-specified sites were tested to compare electrode threshold data, facing both toward and away from the epicardial surface. Results In 151 paired electrode recordings (70 in 6 dogs; 81 in 5 swine), thresholds facing myocardium were lower than those facing away (median threshold of 0.9 [interquartile range (IQR): 0.4 to 1.6] mA vs. 4.6 [IQR: 2.1 to &gt;10.0] mA, respectively, for dogs, p &lt; 0.0001; and 0.5 [IQR: 0.2 to 1.0] mA

Název v anglickém jazyce

Percutaneous Epicardial Pacing Using a Novel Insulated Multi-Electrode Lead

Popis výsledku anglicky

Objectives This study hypothesized that shielded electrodes could capture myocardium without extracardiac stimulation. Background Epicardial cardiac resynchronization therapy (CRT) permits unrestricted electrode positioning. However, this therapy requires surgical placement of device leads and risks unwanted phrenic nerve stimulation. Methods In 6 dog and 5 swine experiments, we used a percutaneous approach to access the epicardial surface of the heart and deployed novel leads housing multiple electrodes with selective insulation. Bipolar pacing thresholds at pre-specified sites were tested to compare electrode threshold data, facing both toward and away from the epicardial surface. Results In 151 paired electrode recordings (70 in 6 dogs; 81 in 5 swine), thresholds facing myocardium were lower than those facing away (median threshold of 0.9 [interquartile range (IQR): 0.4 to 1.6] mA vs. 4.6 [IQR: 2.1 to &gt;10.0] mA, respectively, for dogs, p &lt; 0.0001; and 0.5 [IQR: 0.2 to 1.0] mA

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FS - Lékařská zařízení, přístroje a vybavení

OECD FORD obor

—

Projekt

<a href="/cs/project/ED1.100%2F02%2F0123" target="_blank" >ED1.100/02/0123: Fakultní nemocnice u sv. Anny v Brně - Mezinárodní centrum klinického výzkumu (FNUSA - ICRC)</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

JACC: Clinical Electrophysiology

ISSN

2405-500X

e-ISSN

—

Svazek periodika

1

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

11

Strana od-do

273-283

Kód UT WoS článku

—

EID výsledku v databázi Scopus

—