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Effect of intraluminal thrombus on growth rate of abdominal aortic aneurysms

Identifikátory výsledku

  • Kód výsledku v IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F19%3A00070953" target="_blank" >RIV/00159816:_____/19:00070953 - isvavai.cz</a>

  • Nalezeny alternativní kódy

    RIV/00216224:14110/19:00110190

  • Výsledek na webu

    <a href="https://www.minervamedica.it/en/journals/international-angiology/article.php?cod=R34Y2019N01A0039" target="_blank" >https://www.minervamedica.it/en/journals/international-angiology/article.php?cod=R34Y2019N01A0039</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.23736/S0392-9590.18.04006-3" target="_blank" >10.23736/S0392-9590.18.04006-3</a>

Alternativní jazyky

  • Jazyk výsledku

    angličtina

  • Název v původním jazyce

    Effect of intraluminal thrombus on growth rate of abdominal aortic aneurysms

  • Popis výsledku v původním jazyce

    Background: Abdominal aortic aneurysm (AAA) includes a variety of morphologies with changing properties. Growth rate is one of the most important factors directly linked to the risk of rupture. Intraluminal thrombus (ILT) covering aortic wall is found in the majority of AAAs. Yet, its role in biomechanical processes in AAA remains unclear. From one point of view ILT can serve as protective factor in reducing wall stress of AAA and thus slow down the growth. Modern concept of multilayered ILT proved active inflammatory processes inside, that can significantly affect the quality of the wall and thus lead to a higher growth rate and higher risk of rupture. The goal of this study was to analyze the effect of ILT on growth rate of AAA and support one of these theories. Methods: Retrospective study of computed tomography angiography scans of AAA of 26 patients was performed. Forty pairs of consecutive scans have been analyzed. Periods between two scans varied. Maximal infrarenal diameter of AAA and size of ILT were measured. AAAs were split into 4 groups according to their initial diameter. Growth rate was calculated for each AAA and linked to the relative size of ILT. These values were statistically evaluated. Results: Negative correlation between relative size of ILT and growth rate was found (P=0.042062). This significant result proved that thicker thrombus slowed down the growth of AAA and vice versa, smaller relative size of ILT was linked to higher growth rate. Conclusions: This finding shows importance of ILT as one of the key factors influencing biomechanical processes inside an AAA. Results of this study may contribute to future researches of this topic.

  • Název v anglickém jazyce

    Effect of intraluminal thrombus on growth rate of abdominal aortic aneurysms

  • Popis výsledku anglicky

    Background: Abdominal aortic aneurysm (AAA) includes a variety of morphologies with changing properties. Growth rate is one of the most important factors directly linked to the risk of rupture. Intraluminal thrombus (ILT) covering aortic wall is found in the majority of AAAs. Yet, its role in biomechanical processes in AAA remains unclear. From one point of view ILT can serve as protective factor in reducing wall stress of AAA and thus slow down the growth. Modern concept of multilayered ILT proved active inflammatory processes inside, that can significantly affect the quality of the wall and thus lead to a higher growth rate and higher risk of rupture. The goal of this study was to analyze the effect of ILT on growth rate of AAA and support one of these theories. Methods: Retrospective study of computed tomography angiography scans of AAA of 26 patients was performed. Forty pairs of consecutive scans have been analyzed. Periods between two scans varied. Maximal infrarenal diameter of AAA and size of ILT were measured. AAAs were split into 4 groups according to their initial diameter. Growth rate was calculated for each AAA and linked to the relative size of ILT. These values were statistically evaluated. Results: Negative correlation between relative size of ILT and growth rate was found (P=0.042062). This significant result proved that thicker thrombus slowed down the growth of AAA and vice versa, smaller relative size of ILT was linked to higher growth rate. Conclusions: This finding shows importance of ILT as one of the key factors influencing biomechanical processes inside an AAA. Results of this study may contribute to future researches of this topic.

Klasifikace

  • Druh

    J<sub>imp</sub> - Článek v periodiku v databázi Web of Science

  • CEP obor

  • OECD FORD obor

    30201 - Cardiac and Cardiovascular systems

Návaznosti výsledku

  • Projekt

  • Návaznosti

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Ostatní

  • Rok uplatnění

    2019

  • Kód důvěrnosti údajů

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Údaje specifické pro druh výsledku

  • Název periodika

    International Angiology

  • ISSN

    0392-9590

  • e-ISSN

  • Svazek periodika

    38

  • Číslo periodika v rámci svazku

    1

  • Stát vydavatele periodika

    IT - Italská republika

  • Počet stran výsledku

    7

  • Strana od-do

    39-45

  • Kód UT WoS článku

    000461074100006

  • EID výsledku v databázi Scopus