Memory outcomes of temporal lobe surgery in adults aged over 45 years

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F21%3A00074681" target="_blank" >RIV/00159816:_____/21:00074681 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/21:00120098

Výsledek na webu

<a href="https://onlinelibrary.wiley.com/doi/10.1111/ane.13427" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1111/ane.13427</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/ane.13427" target="_blank" >10.1111/ane.13427</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Memory outcomes of temporal lobe surgery in adults aged over 45 years

Popis výsledku v původním jazyce

Objective It is assumed that temporal lobe resection in older people is associated with worse seizure outcomes and potential postsurgical memory decline. We studied postsurgical memory development and surgical efficacy in patients over 45 years of age compared with younger patients. Methods We studied 88 patients (51 male and 37 female) after temporal lobe surgery, which involved hippocampal resection. The patients were evaluated before surgery and in the first (72 patients) and/or third (57 patients) postsurgical year. The Wechsler Memory Scale III test was performed to evaluate the MQ postsurgical development. Engel&apos;s classification was used to evaluate the postsurgical seizure outcome. Results The presurgical MQ (median 88) in &gt;= 45 years age group was significantly lower than in both younger groups (median MQ = 100 for &lt;= 30 years age group, p = 0.002; median MQ = 107 for 31-44 years age group, p = 0.002). Three years after the surgery, the MQ decreased significantly in &lt;= 30 years age group (p = 0.012), while only non-significant MQ decline was observed in both older groups. We found no significant impact of age on the surgical outcome. Conclusion Higher age at the time of surgery does not significantly increase the risk for postsurgical memory decline; however, older patients are more likely to have lowered presurgical MQ. We did not find significant differences in the impact of surgery on seizure outcome among the age groups. Epilepsy surgery appears to be a safe and effective method in the age over 45 years even though an earlier surgery should be preferred.

Název v anglickém jazyce

Memory outcomes of temporal lobe surgery in adults aged over 45 years

Popis výsledku anglicky

Objective It is assumed that temporal lobe resection in older people is associated with worse seizure outcomes and potential postsurgical memory decline. We studied postsurgical memory development and surgical efficacy in patients over 45 years of age compared with younger patients. Methods We studied 88 patients (51 male and 37 female) after temporal lobe surgery, which involved hippocampal resection. The patients were evaluated before surgery and in the first (72 patients) and/or third (57 patients) postsurgical year. The Wechsler Memory Scale III test was performed to evaluate the MQ postsurgical development. Engel&apos;s classification was used to evaluate the postsurgical seizure outcome. Results The presurgical MQ (median 88) in &gt;= 45 years age group was significantly lower than in both younger groups (median MQ = 100 for &lt;= 30 years age group, p = 0.002; median MQ = 107 for 31-44 years age group, p = 0.002). Three years after the surgery, the MQ decreased significantly in &lt;= 30 years age group (p = 0.012), while only non-significant MQ decline was observed in both older groups. We found no significant impact of age on the surgical outcome. Conclusion Higher age at the time of surgery does not significantly increase the risk for postsurgical memory decline; however, older patients are more likely to have lowered presurgical MQ. We did not find significant differences in the impact of surgery on seizure outcome among the age groups. Epilepsy surgery appears to be a safe and effective method in the age over 45 years even though an earlier surgery should be preferred.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30210 - Clinical neurology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Acta neurologica Scandinavica

ISSN

0001-6314

e-ISSN

—

Svazek periodika

144

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

11

Strana od-do

81-91

Kód UT WoS článku

000641828400001

EID výsledku v databázi Scopus

—