Bidirectional Association Between Sleep and Brain Atrophy in Aging

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F21%3A00074986" target="_blank" >RIV/00159816:_____/21:00074986 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/21:10437732 RIV/65269705:_____/21:00074986 RIV/00064165:_____/21:10437732 RIV/00216224:14110/21:00123751

Výsledek na webu

<a href="https://www.frontiersin.org/articles/10.3389/fnagi.2021.726662/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fnagi.2021.726662/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fnagi.2021.726662" target="_blank" >10.3389/fnagi.2021.726662</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Bidirectional Association Between Sleep and Brain Atrophy in Aging

Popis výsledku v původním jazyce

Human brain aging is characterized by the gradual deterioration of its function and structure, affected by the interplay of a multitude of causal factors. The sleep, a periodically repeating state of reversible unconsciousness characterized by distinct electrical brain activity, is crucial for maintaining brain homeostasis. Indeed, insufficient sleep was associated with accelerated brain atrophy and impaired brain functional connectivity. Concurrently, alteration of sleep-related transient electrical events in senescence was correlated with structural and functional deterioration of brain regions responsible for their generation, implying the interconnectedness of sleep and brain structure. This review discusses currently available data on the link between human brain aging and sleep derived from various neuroimaging and neurophysiological methods. We advocate the notion of a mutual relationship between the sleep structure and age-related alterations of functional and structural brain integrity, pointing out the position of high-quality sleep as a potent preventive factor of early brain aging and neurodegeneration. However, further studies are needed to reveal the causality of the relationship between sleep and brain aging.

Název v anglickém jazyce

Bidirectional Association Between Sleep and Brain Atrophy in Aging

Popis výsledku anglicky

Human brain aging is characterized by the gradual deterioration of its function and structure, affected by the interplay of a multitude of causal factors. The sleep, a periodically repeating state of reversible unconsciousness characterized by distinct electrical brain activity, is crucial for maintaining brain homeostasis. Indeed, insufficient sleep was associated with accelerated brain atrophy and impaired brain functional connectivity. Concurrently, alteration of sleep-related transient electrical events in senescence was correlated with structural and functional deterioration of brain regions responsible for their generation, implying the interconnectedness of sleep and brain structure. This review discusses currently available data on the link between human brain aging and sleep derived from various neuroimaging and neurophysiological methods. We advocate the notion of a mutual relationship between the sleep structure and age-related alterations of functional and structural brain integrity, pointing out the position of high-quality sleep as a potent preventive factor of early brain aging and neurodegeneration. However, further studies are needed to reveal the causality of the relationship between sleep and brain aging.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Frontiers in Aging Neuroscience

ISSN

1663-4365

e-ISSN

—

Svazek periodika

13

Číslo periodika v rámci svazku

DEC 8

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

7

Strana od-do

726662

Kód UT WoS článku

000732956300001

EID výsledku v databázi Scopus

2-s2.0-85121631830