Brain Regional Glucose Metabolism, Neuropsychiatric Symptoms, and the Risk of Incident Mild Cognitive Impairment: The Mayo Clinic Study of Aging

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F21%3A00075149" target="_blank" >RIV/00159816:_____/21:00075149 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S1064748120303754?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1064748120303754?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jagp.2020.06.006" target="_blank" >10.1016/j.jagp.2020.06.006</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Brain Regional Glucose Metabolism, Neuropsychiatric Symptoms, and the Risk of Incident Mild Cognitive Impairment: The Mayo Clinic Study of Aging

Popis výsledku v původním jazyce

Objective: The authors conducted a prospective cohort study to examine the risk of incident mild cognitive impairment (MCI) as predicted by baseline neuropsychiatric symptoms (NPS) and brain regional glucose metabolic dysfunction. Methods: About 1,363 cognitively unimpaired individuals (52.8% males) aged &gt;= 50 years were followed for a median of 4.8 years to the outcome of incident MCI. NPS were assessed using Beck Depression and Anxiety Inventories and Neuropsychiatric Inventory Questionnaire. Glucose hypometabolism was measured by fluorodeoxyglucose positron emission tomography and defined as standardized uptake value ratio &lt;= 1.47 in regions typically affected in Alzheimer disease. Cox proportional hazards models were adjusted for age, sex, education, and APOE epsilon 4 status. Results: Participants with regional glucose hypometabolism and depression (Beck Depression Inventory-II &gt;= 13) had a more than threefold increased risk of incident MCI (hazard ratio [95% confidence interval], 3.66 [1.75, 7.65], p &lt;0.001, chi(2) = 11.83, degree of freedom [df] =1) as compared to the reference group (normal regional glucose metabolism and no depression), and the risk was also significantly elevated (7.21 13.54, 14.7], p &lt;0.001, f = 29.68, df =1) for participants with glucose hypometabolism and anxiety (Beck Anxiety Inventory &gt;= 10). Having glucose hypometabolism and &gt;= 1 NPS (3. 74 12.40, 5.82], p &lt;0.001, chi(2) = 34. 13, df =1) or &gt;= 2 NPS (3.89 12.20, 686], p &lt;0.001, chi(2) = 21.92, df = 1) increased the risk of incident MCI by more than three times, and having &gt;= 3 NPS increased the risk by more than four times (4.12 12.03, 8.3 7], p &lt;0.001, chi(2) = 15.39, df =1). Conclusion: Combined presence of NPS with regional glucose hypometabolism is associated with an increased risk of incident MCI, with fluorodeoxyglucose positron emission tomography appearing to be a stronger driving force of cognitive decline than NPS.

Název v anglickém jazyce

Brain Regional Glucose Metabolism, Neuropsychiatric Symptoms, and the Risk of Incident Mild Cognitive Impairment: The Mayo Clinic Study of Aging

Popis výsledku anglicky

Objective: The authors conducted a prospective cohort study to examine the risk of incident mild cognitive impairment (MCI) as predicted by baseline neuropsychiatric symptoms (NPS) and brain regional glucose metabolic dysfunction. Methods: About 1,363 cognitively unimpaired individuals (52.8% males) aged &gt;= 50 years were followed for a median of 4.8 years to the outcome of incident MCI. NPS were assessed using Beck Depression and Anxiety Inventories and Neuropsychiatric Inventory Questionnaire. Glucose hypometabolism was measured by fluorodeoxyglucose positron emission tomography and defined as standardized uptake value ratio &lt;= 1.47 in regions typically affected in Alzheimer disease. Cox proportional hazards models were adjusted for age, sex, education, and APOE epsilon 4 status. Results: Participants with regional glucose hypometabolism and depression (Beck Depression Inventory-II &gt;= 13) had a more than threefold increased risk of incident MCI (hazard ratio [95% confidence interval], 3.66 [1.75, 7.65], p &lt;0.001, chi(2) = 11.83, degree of freedom [df] =1) as compared to the reference group (normal regional glucose metabolism and no depression), and the risk was also significantly elevated (7.21 13.54, 14.7], p &lt;0.001, f = 29.68, df =1) for participants with glucose hypometabolism and anxiety (Beck Anxiety Inventory &gt;= 10). Having glucose hypometabolism and &gt;= 1 NPS (3. 74 12.40, 5.82], p &lt;0.001, chi(2) = 34. 13, df =1) or &gt;= 2 NPS (3.89 12.20, 686], p &lt;0.001, chi(2) = 21.92, df = 1) increased the risk of incident MCI by more than three times, and having &gt;= 3 NPS increased the risk by more than four times (4.12 12.03, 8.3 7], p &lt;0.001, chi(2) = 15.39, df =1). Conclusion: Combined presence of NPS with regional glucose hypometabolism is associated with an increased risk of incident MCI, with fluorodeoxyglucose positron emission tomography appearing to be a stronger driving force of cognitive decline than NPS.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30227 - Geriatrics and gerontology

Projekt

<a href="/cs/project/LQ1605" target="_blank" >LQ1605: Translační medicína</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

American Journal of Geriatric Psychiatry

ISSN

1064-7481

e-ISSN

—

Svazek periodika

29

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

13

Strana od-do

179-191

Kód UT WoS článku

000632165600002

EID výsledku v databázi Scopus

—