Kinetics of procalcitonin, C-reactive protein and interleukin-6 in cardiogenic shock – Insights from the CardShock study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F21%3A00075875" target="_blank" >RIV/00159816:_____/21:00075875 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/21:00120857 RIV/00159816:_____/21:00075836

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/abs/pii/S0167527320336524?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S0167527320336524?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ijcard.2020.08.069" target="_blank" >10.1016/j.ijcard.2020.08.069</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Kinetics of procalcitonin, C-reactive protein and interleukin-6 in cardiogenic shock – Insights from the CardShock study

Popis výsledku v původním jazyce

Background: Inflammatory responses play an important role in the pathophysiology of cardiogenic shock (CS). The aim of this study was to investigate the kinetics of procalcitonin (PCT), C-reactive protein (CRP), and interleukin-6 (IL-6) in CS and to assess their relation to clinical presentation, other biochemical variables, and prognosis. Methods: Levels of PCT, CRP and IL-6 were analyzed in serial plasma samples (0MINUS SIGN 120h) from 183 patients in the CardShock study. The study population was dichotomized by PCTmax GREATER-THAN OR EQUAL TO and &lt; 0.5 μg/L, and IL-6 and CRPmax above/below median. Results: PCT peaked already at 24 h [median PCTmax 0.71 μg/L (IQR 0.24-3.4)], whereas CRP peaked later between 48 and 72 h [median CRPmax 137 mg/L (59-247)]. PCT levels were significantly higher among non-survivors compared with survivors from 12 h on, as were CRP levels from 24 h on (p &lt; 0.001). PCTmax GREATER-THAN OR EQUAL TO 0.5 μg/L (60% of patients) was associated with clinical signs of systemic hypoperfusion, cardiac and renal dysfunction, acidosis, and higher levels of blood lactate, IL-6, growth-differentiation factor 15 (GDF-15), and CRPmax. Similarly, IL-6 &gt; median was associated with clinical signs and biochemical findings of systemic hypoperfusion. PCTmax GREATER-THAN OR EQUAL TO 0.5 μg/L and IL-6 &gt; median were associated with increased 90-day mortality (50% vs. 30% and 57% vs. 22%, respectively; p &lt; 0.01 for both), while CRPmax showed no prognostic significance. The association of inflammatory markers with clinical infections was modest. Conclusions: Inflammatory markers are highly related to signs of systemic hypoperfusion in CS. Moreover, high PCT and IL-6 levels are associated with poor prognosis. (C) 2020 Elsevier B.V.

Název v anglickém jazyce

Kinetics of procalcitonin, C-reactive protein and interleukin-6 in cardiogenic shock – Insights from the CardShock study

Popis výsledku anglicky

Background: Inflammatory responses play an important role in the pathophysiology of cardiogenic shock (CS). The aim of this study was to investigate the kinetics of procalcitonin (PCT), C-reactive protein (CRP), and interleukin-6 (IL-6) in CS and to assess their relation to clinical presentation, other biochemical variables, and prognosis. Methods: Levels of PCT, CRP and IL-6 were analyzed in serial plasma samples (0MINUS SIGN 120h) from 183 patients in the CardShock study. The study population was dichotomized by PCTmax GREATER-THAN OR EQUAL TO and &lt; 0.5 μg/L, and IL-6 and CRPmax above/below median. Results: PCT peaked already at 24 h [median PCTmax 0.71 μg/L (IQR 0.24-3.4)], whereas CRP peaked later between 48 and 72 h [median CRPmax 137 mg/L (59-247)]. PCT levels were significantly higher among non-survivors compared with survivors from 12 h on, as were CRP levels from 24 h on (p &lt; 0.001). PCTmax GREATER-THAN OR EQUAL TO 0.5 μg/L (60% of patients) was associated with clinical signs of systemic hypoperfusion, cardiac and renal dysfunction, acidosis, and higher levels of blood lactate, IL-6, growth-differentiation factor 15 (GDF-15), and CRPmax. Similarly, IL-6 &gt; median was associated with clinical signs and biochemical findings of systemic hypoperfusion. PCTmax GREATER-THAN OR EQUAL TO 0.5 μg/L and IL-6 &gt; median were associated with increased 90-day mortality (50% vs. 30% and 57% vs. 22%, respectively; p &lt; 0.01 for both), while CRPmax showed no prognostic significance. The association of inflammatory markers with clinical infections was modest. Conclusions: Inflammatory markers are highly related to signs of systemic hypoperfusion in CS. Moreover, high PCT and IL-6 levels are associated with poor prognosis. (C) 2020 Elsevier B.V.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Cardiology

ISSN

0167-5273

e-ISSN

—

Svazek periodika

322

Číslo periodika v rámci svazku

322

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

191-196

Kód UT WoS článku

000612679700043

EID výsledku v databázi Scopus

2-s2.0-85090155798