Serial measurement of presepsin, procalcitonin, and C-reactive protein in the early postoperative period and the response to antithymocyte globulin administration after heart transplantation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F17%3A43912361" target="_blank" >RIV/00216208:11120/17:43912361 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023001:_____/17:00060199

Výsledek na webu

<a href="http://dx.doi.org/10.1111/ctr.12870" target="_blank" >http://dx.doi.org/10.1111/ctr.12870</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/ctr.12870" target="_blank" >10.1111/ctr.12870</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Serial measurement of presepsin, procalcitonin, and C-reactive protein in the early postoperative period and the response to antithymocyte globulin administration after heart transplantation

Popis výsledku v původním jazyce

Differentiation between systemic inflammatory response syndrome (SIRS) and sepsis in surgical patients is of crucial significance. Procalcitonin (PCT) and C-reactive protein (CRP) are widely used biomarkers, but PCT becomes compromised after antithymocyte globulin (ATG) administration, and CRP exhibits limited specificity. Presepsin has been suggested as an alternative biomarker of sepsis. This study aims to demonstrate the role of presepsin in patients after heart transplantation (HTx). Plasma presepsin, PCT and CRP were measured in 107 patients serially for up to 10 days following HTx. Time responses of biomarkers were evaluated for both noninfected (N=91) and infected (N=16) patients. Areas under the concentration curve (AUC) differed in the two groups of patients for presepsin (p&lt;0.001), PCT (p&lt;0.005) and CRP (p&lt;0.001). The effect of time and infection was significant for all three biomarkers (p&lt;0.05 all). In contrast to PCT, presepsin was not influenced by ATG administration. More than 25% of noninfected patients had PCT above 42 μg/L on the 1(st) day and the peak concentration of CRP in infected patients was reached on the 3(rd) posttransplant day (median 135 mg/L). Presepsin seems to be as valuable a biomarker as PCT or CRP in the evaluation of infectious complications in patients after HTx.

Název v anglickém jazyce

Serial measurement of presepsin, procalcitonin, and C-reactive protein in the early postoperative period and the response to antithymocyte globulin administration after heart transplantation

Popis výsledku anglicky

Differentiation between systemic inflammatory response syndrome (SIRS) and sepsis in surgical patients is of crucial significance. Procalcitonin (PCT) and C-reactive protein (CRP) are widely used biomarkers, but PCT becomes compromised after antithymocyte globulin (ATG) administration, and CRP exhibits limited specificity. Presepsin has been suggested as an alternative biomarker of sepsis. This study aims to demonstrate the role of presepsin in patients after heart transplantation (HTx). Plasma presepsin, PCT and CRP were measured in 107 patients serially for up to 10 days following HTx. Time responses of biomarkers were evaluated for both noninfected (N=91) and infected (N=16) patients. Areas under the concentration curve (AUC) differed in the two groups of patients for presepsin (p&lt;0.001), PCT (p&lt;0.005) and CRP (p&lt;0.001). The effect of time and infection was significant for all three biomarkers (p&lt;0.05 all). In contrast to PCT, presepsin was not influenced by ATG administration. More than 25% of noninfected patients had PCT above 42 μg/L on the 1(st) day and the peak concentration of CRP in infected patients was reached on the 3(rd) posttransplant day (median 135 mg/L). Presepsin seems to be as valuable a biomarker as PCT or CRP in the evaluation of infectious complications in patients after HTx.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

<a href="/cs/project/NV15-27579A" target="_blank" >NV15-27579A: Monoklonální gamapatie u pacientů po transplantaci solidních orgánů. Vztah mezi potransplantační imunosupresí a lymfoproliferativními onemocněními.</a><br>

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clinical Transplantation

ISSN

0902-0063

e-ISSN

—

Svazek periodika

31

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

"e12870"

Kód UT WoS článku

000392436100010

EID výsledku v databázi Scopus

2-s2.0-85006415898