Changes in Sepsis Biomarkers after Immunosuppressant Administration in Transplant Patients

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F21%3A00080761" target="_blank" >RIV/00023001:_____/21:00080761 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11120/21:43921078 RIV/00216208:11110/21:10421862

Výsledek na webu

<a href="https://downloads.hindawi.com/journals/mi/2021/8831659.pdf" target="_blank" >https://downloads.hindawi.com/journals/mi/2021/8831659.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1155/2021/8831659" target="_blank" >10.1155/2021/8831659</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Changes in Sepsis Biomarkers after Immunosuppressant Administration in Transplant Patients

Popis výsledku v původním jazyce

Sepsis biomarkers change continuously during the postoperative period. We aimed to demonstrate the influence of immunosuppressants after transplantation (Tx) on presepsin, procalcitonin, CRP, white blood cells, and IL-6. A group of 140 patients after major surgery (86 non-Tx, 54 Tx) without any signs of sepsis or infectious complications was followed for 7 days. The changes in biomarkers were analyzed with respect to the type of surgery, organ, and induction immunosuppressant used (antithymocyte globulin, corticosteroids, or basiliximab/rituximab). Concentrations (95th percentiles) of presepsin and procalcitonin were higher in the Tx group (presepsin: Tx&lt;2380 vs. non-Tx&lt;1368 ng/L, p&lt;0.05; procalcitonin: &lt;28.0 vs. 3.49 μg/L, p&lt;0.05). In contrast, CRP and IL-6 were lower in the Tx group (CRP: Tx&lt;84.2 vs. non-Tx&lt;229 mg/L, p&lt;0.05; IL-6: &lt;71.2 vs. 317 ng/L, p&lt;0.05). Decreases in CRP and IL-6 were found for all immunosuppressants, and procalcitonin was increased after antithymocyte globulin and corticosteroids. Negligible changes were found for white blood cells. Different responses of presepsin, procalcitonin, CRP, and IL-6 were therefore found in patients without any infectious complications after major surgery or transplantation. Immunosuppression decreased significantly IL-6 and CRP in comparison to non-Tx patients, while procalcitonin was increased after corticosteroids and antithymocyte globulin only. Cautious interpretation of sepsis biomarkers is needed in the early posttransplant period. This work was conducted as a noninterventional (nonregistered) study. © 2021 Janka Franeková et al.

Název v anglickém jazyce

Changes in Sepsis Biomarkers after Immunosuppressant Administration in Transplant Patients

Popis výsledku anglicky

Sepsis biomarkers change continuously during the postoperative period. We aimed to demonstrate the influence of immunosuppressants after transplantation (Tx) on presepsin, procalcitonin, CRP, white blood cells, and IL-6. A group of 140 patients after major surgery (86 non-Tx, 54 Tx) without any signs of sepsis or infectious complications was followed for 7 days. The changes in biomarkers were analyzed with respect to the type of surgery, organ, and induction immunosuppressant used (antithymocyte globulin, corticosteroids, or basiliximab/rituximab). Concentrations (95th percentiles) of presepsin and procalcitonin were higher in the Tx group (presepsin: Tx&lt;2380 vs. non-Tx&lt;1368 ng/L, p&lt;0.05; procalcitonin: &lt;28.0 vs. 3.49 μg/L, p&lt;0.05). In contrast, CRP and IL-6 were lower in the Tx group (CRP: Tx&lt;84.2 vs. non-Tx&lt;229 mg/L, p&lt;0.05; IL-6: &lt;71.2 vs. 317 ng/L, p&lt;0.05). Decreases in CRP and IL-6 were found for all immunosuppressants, and procalcitonin was increased after antithymocyte globulin and corticosteroids. Negligible changes were found for white blood cells. Different responses of presepsin, procalcitonin, CRP, and IL-6 were therefore found in patients without any infectious complications after major surgery or transplantation. Immunosuppression decreased significantly IL-6 and CRP in comparison to non-Tx patients, while procalcitonin was increased after corticosteroids and antithymocyte globulin only. Cautious interpretation of sepsis biomarkers is needed in the early posttransplant period. This work was conducted as a noninterventional (nonregistered) study. © 2021 Janka Franeková et al.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30213 - Transplantation

Projekt

<a href="/cs/project/NV15-27579A" target="_blank" >NV15-27579A: Monoklonální gamapatie u pacientů po transplantaci solidních orgánů. Vztah mezi potransplantační imunosupresí a lymfoproliferativními onemocněními.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Mediators of inflammation [online]

ISSN

0962-9351

e-ISSN

—

Svazek periodika

2021

Číslo periodika v rámci svazku

Januar

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

9

Strana od-do

"art. no. 8831659"

Kód UT WoS článku

000612237700002

EID výsledku v databázi Scopus

2-s2.0-85099617370