Predicting DWI-FLAIR mismatch on NCCT: the role of artificial intelligence in hyperacute decision making
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F23%3A00078764" target="_blank" >RIV/00159816:_____/23:00078764 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216224:14110/23:00133283
Výsledek na webu
<a href="https://www.frontiersin.org/articles/10.3389/fneur.2023.1201223/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fneur.2023.1201223/full</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fneur.2023.1201223" target="_blank" >10.3389/fneur.2023.1201223</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Predicting DWI-FLAIR mismatch on NCCT: the role of artificial intelligence in hyperacute decision making
Popis výsledku v původním jazyce
BackgroundThe presence of diffusion-weighted imaging (DWI) and fluid-attenuated inversion recovery (FLAIR) mismatch was used to determine eligibility for intravenous thrombolysis in clinical trials. However, due to the restricted availability of MRI and the ambiguity of image assessment, it is not widely implemented in clinical practice. MethodsA total of 222 acute ischemic stroke patients underwent non-contrast computed tomography (NCCT), DWI, and FLAIR within 1 h of one another. Human experts manually segmented ischemic lesions on DWI and FLAIR images and independently graded the presence of DWI-FLAIR mismatch. Deep learning (DL) models based on the nnU-net architecture were developed to predict ischemic lesions visible on DWI and FLAIR images using NCCT images. Inexperienced neurologists evaluated the DWI-FLAIR mismatch on NCCT images without and with the model's results. ResultsThe mean age of included subjects was 71.8 & PLUSMN; 12.8 years, 123 (55%) were male, and the baseline NIHSS score was a median of 11 [IQR, 6-18]. All images were taken in the following order: NCCT - DWI - FLAIR, starting after a median of 139 [81-326] min after the time of the last known well. Intravenous thrombolysis was administered in 120 patients (54%) after NCCT. The DL model's prediction on NCCT images revealed a Dice coefficient and volume correlation of 39.1% and 0.76 for DWI lesions and 18.9% and 0.61 for FLAIR lesions. In the subgroup with 15 mL or greater lesion volume, the evaluation of DWI-FLAIR mismatch from NCCT by inexperienced neurologists improved in accuracy (from 0.537 to 0.610) and AUC-ROC (from 0.493 to 0.613). ConclusionThe DWI-FLAIR mismatch may be reckoned using NCCT images through advanced artificial intelligence techniques.
Název v anglickém jazyce
Predicting DWI-FLAIR mismatch on NCCT: the role of artificial intelligence in hyperacute decision making
Popis výsledku anglicky
BackgroundThe presence of diffusion-weighted imaging (DWI) and fluid-attenuated inversion recovery (FLAIR) mismatch was used to determine eligibility for intravenous thrombolysis in clinical trials. However, due to the restricted availability of MRI and the ambiguity of image assessment, it is not widely implemented in clinical practice. MethodsA total of 222 acute ischemic stroke patients underwent non-contrast computed tomography (NCCT), DWI, and FLAIR within 1 h of one another. Human experts manually segmented ischemic lesions on DWI and FLAIR images and independently graded the presence of DWI-FLAIR mismatch. Deep learning (DL) models based on the nnU-net architecture were developed to predict ischemic lesions visible on DWI and FLAIR images using NCCT images. Inexperienced neurologists evaluated the DWI-FLAIR mismatch on NCCT images without and with the model's results. ResultsThe mean age of included subjects was 71.8 & PLUSMN; 12.8 years, 123 (55%) were male, and the baseline NIHSS score was a median of 11 [IQR, 6-18]. All images were taken in the following order: NCCT - DWI - FLAIR, starting after a median of 139 [81-326] min after the time of the last known well. Intravenous thrombolysis was administered in 120 patients (54%) after NCCT. The DL model's prediction on NCCT images revealed a Dice coefficient and volume correlation of 39.1% and 0.76 for DWI lesions and 18.9% and 0.61 for FLAIR lesions. In the subgroup with 15 mL or greater lesion volume, the evaluation of DWI-FLAIR mismatch from NCCT by inexperienced neurologists improved in accuracy (from 0.537 to 0.610) and AUC-ROC (from 0.493 to 0.613). ConclusionThe DWI-FLAIR mismatch may be reckoned using NCCT images through advanced artificial intelligence techniques.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
30210 - Clinical neurology
Návaznosti výsledku
Projekt
—
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2023
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Frontiers in Neurology
ISSN
1664-2295
e-ISSN
—
Svazek periodika
14
Číslo periodika v rámci svazku
JUN 12
Stát vydavatele periodika
CH - Švýcarská konfederace
Počet stran výsledku
10
Strana od-do
1201223
Kód UT WoS článku
001013166500001
EID výsledku v databázi Scopus
2-s2.0-85163631325