Mid- and Late-Life Physical Activity and Neuropsychiatric Symptoms in Dementia-Free Older Adults: Mayo Clinic Study of Aging

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F23%3A00079647" target="_blank" >RIV/00159816:_____/23:00079647 - isvavai.cz</a>

Výsledek na webu

<a href="https://neuro.psychiatryonline.org/doi/10.1176/appi.neuropsych.20220068" target="_blank" >https://neuro.psychiatryonline.org/doi/10.1176/appi.neuropsych.20220068</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1176/appi.neuropsych.20220068" target="_blank" >10.1176/appi.neuropsych.20220068</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Mid- and Late-Life Physical Activity and Neuropsychiatric Symptoms in Dementia-Free Older Adults: Mayo Clinic Study of Aging

Popis výsledku v původním jazyce

Objective: This study examined associations between physical activity (PA) and neuropsychiatric symptoms (NPS) in older adults free of dementia.Methods: This cross-sectional study included 3,222 individuals $70 years of age (1,655 men; mean +/- SD age=79.2 +/- 5.6; cognitively unimpaired, N= 2,723; mild cognitive impairment, N=499) from the population-based Mayo Clinic Study of Aging. PA (taken as a presumed pre-dictor) in midlife (i.e., when participants were 50-65 years of age) and late life (i.e., the year prior to assessment) was assessed with a self-reported, validated questionnaire; PA intensity and frequency were used to calculate composite scores. NPS (taken as presumed outcomes) were assessed with the Neuropsychiatric Inventory Questionnaire, Beck Depression Inventory (BDI-II), and Beck Anxiety Inventory (BAI). Regression analyses included midlife and late-life PA in each model, which were adjusted for age, sex, education, apolipoprotein E e4 status, and medical comorbidity. Results: Higher late-life PA was associated with lower odds of having apathy (OR=0.89, 95% CI=0.84-0.93), appetite changes (OR=0.92, 95% CI=0.87-0.98), nighttime distur-bances (OR=0.95, 95% CI=0.91-0.99), depression (OR=0.94, 95% CI=0.90-0.97), irritability (OR=0.93, 95% CI=0.89-0.97), clinical depression (OR=0.92, 95% CI=0.88-0.97), and clinical anxiety (OR=0.90, 95% CI=0.86-0.94), as well as lower BDI-II (8 estimate=-0.042, 95% CI=-0.051 to-0.033) and BAI (8 estimate=-0.030, 95% CI=-0.040 to-0.021) scores. Higher midlife PA was associated only with higher BDI-II scores (8 estimate=0.011, 95% CI=0.004 to 0.019). Sex modified the associations between PA and NPS.Conclusions: Late-life PA was associated with a lower like-lihood of clinical depression or anxiety and subclinical NPS. These findings need to be confirmed in a cohort study.

Název v anglickém jazyce

Mid- and Late-Life Physical Activity and Neuropsychiatric Symptoms in Dementia-Free Older Adults: Mayo Clinic Study of Aging

Popis výsledku anglicky

Objective: This study examined associations between physical activity (PA) and neuropsychiatric symptoms (NPS) in older adults free of dementia.Methods: This cross-sectional study included 3,222 individuals $70 years of age (1,655 men; mean +/- SD age=79.2 +/- 5.6; cognitively unimpaired, N= 2,723; mild cognitive impairment, N=499) from the population-based Mayo Clinic Study of Aging. PA (taken as a presumed pre-dictor) in midlife (i.e., when participants were 50-65 years of age) and late life (i.e., the year prior to assessment) was assessed with a self-reported, validated questionnaire; PA intensity and frequency were used to calculate composite scores. NPS (taken as presumed outcomes) were assessed with the Neuropsychiatric Inventory Questionnaire, Beck Depression Inventory (BDI-II), and Beck Anxiety Inventory (BAI). Regression analyses included midlife and late-life PA in each model, which were adjusted for age, sex, education, apolipoprotein E e4 status, and medical comorbidity. Results: Higher late-life PA was associated with lower odds of having apathy (OR=0.89, 95% CI=0.84-0.93), appetite changes (OR=0.92, 95% CI=0.87-0.98), nighttime distur-bances (OR=0.95, 95% CI=0.91-0.99), depression (OR=0.94, 95% CI=0.90-0.97), irritability (OR=0.93, 95% CI=0.89-0.97), clinical depression (OR=0.92, 95% CI=0.88-0.97), and clinical anxiety (OR=0.90, 95% CI=0.86-0.94), as well as lower BDI-II (8 estimate=-0.042, 95% CI=-0.051 to-0.033) and BAI (8 estimate=-0.030, 95% CI=-0.040 to-0.021) scores. Higher midlife PA was associated only with higher BDI-II scores (8 estimate=0.011, 95% CI=0.004 to 0.019). Sex modified the associations between PA and NPS.Conclusions: Late-life PA was associated with a lower like-lihood of clinical depression or anxiety and subclinical NPS. These findings need to be confirmed in a cohort study.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

30210 - Clinical neurology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Neuropsychiatry and Clinical Neurosciences

ISSN

0895-0172

e-ISSN

1545-7222

Svazek periodika

35

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

133-140

Kód UT WoS článku

001008293100004

EID výsledku v databázi Scopus

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