Causes of ventilatory inefficiency in lung resection candidates
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F25%3A00081682" target="_blank" >RIV/00159816:_____/25:00081682 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216224:14110/25:00140639
Výsledek na webu
<a href="https://publications.ersnet.org/content/erjor/11/2/00792-2024" target="_blank" >https://publications.ersnet.org/content/erjor/11/2/00792-2024</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1183/23120541.00792-2024" target="_blank" >10.1183/23120541.00792-2024</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Causes of ventilatory inefficiency in lung resection candidates
Popis výsledku v původním jazyce
Introduction Ventilatory efficiency (V'E/V'CO2) has been shown to predict postoperative pulmonary complications (PPCs) in lung resection candidates. V'E/V'CO2 is determined by arterial partial pressure of carbon dioxide (PaCO2) and by dead space to tidal volume ratio (VD/VT). We hypothesised PaCO2 and VD /VT contribute equally to the increase in V'E/V'CO2 in lung resection patients. Methods Consecutive lung resection candidates from two prior prospective studies were included in this post hoc analysis. All subjects underwent preoperative spirometry, cardiopulmonary exercise testing and arterial blood gas analysis at rest and peak exercise. PPCs were prospectively assessed during the first 30 postoperative days, or hospital stay. A t-test, Mann-Whitney U-test and two-tailed Fisher's exact test were used to compare patients with and without PPCs. p-values <0.05 were considered statistically significant. Results Of 398 patients, PPC developed in 64 (16%). Patients with PPCs more frequently underwent lobectomy by open thoracotomy, had longer hospital and ICU length of stay and higher 30-and 90-day mortality. Moreover, patients with PPCs exhibited a higher V'E/V'CO2 ratio both at rest and peak exercise. Both ratios were independently associated with PPCs. At rest, the contribution of PaCO2 and VD/VT to the increase in V'E/V'CO2 ratio in patients with PPCs was 45% and 55%, respectively. At peak exercise, the contribution of PaCO2 and VD/VT to the increase in V'E/V'CO2 ratio was 16% and 84%, respectively. Conclusions VD/VT (V'/Q' mismatch and/or rapid shallow breathing pattern) is the dominant contributor to the increase in V'E/V'CO2 in lung resection candidates who develop PPCs.Methods: Consecutive lung resection candidates from two prior prospective studies were included inthis post-hoc analysis. All subjects underwent preoperative spirometry, cardiopulmonary exercisetesting and arterial blood gas analysis at rest and peak exercise. PPC were prospectively assessedduring the first 30 post-operative days, or hospital stay. Student t-test, Mann-Whitney U test and two-tailed Fisher exact test were used to compare patients with and without PPC. P values <0.05 wereconsidered statistically significant.Results: Of 398 patients, PPC developed in 64 (16%). Patients with PPC more frequently underwentlobectomy by open thoracotomy, had longer hospital and ICU length of stay and higher 30- and 90-day mortality. Moreover, patients with PPC exhibited higher VE/VCO2 ratio both at rest and peakexercise. Both ratios were independently associated with PPC. At rest, the contribution of PaCO2 andVD/VT to the increase in VE/VCO2 ratio in patients with PPC was 45% and 55%, respectively. At peakexercise, the contribution of PaCO2 and VD/VT to the increase in VE/VCO2 ratio was 16% and 84 %,respectively
Název v anglickém jazyce
Causes of ventilatory inefficiency in lung resection candidates
Popis výsledku anglicky
Introduction Ventilatory efficiency (V'E/V'CO2) has been shown to predict postoperative pulmonary complications (PPCs) in lung resection candidates. V'E/V'CO2 is determined by arterial partial pressure of carbon dioxide (PaCO2) and by dead space to tidal volume ratio (VD/VT). We hypothesised PaCO2 and VD /VT contribute equally to the increase in V'E/V'CO2 in lung resection patients. Methods Consecutive lung resection candidates from two prior prospective studies were included in this post hoc analysis. All subjects underwent preoperative spirometry, cardiopulmonary exercise testing and arterial blood gas analysis at rest and peak exercise. PPCs were prospectively assessed during the first 30 postoperative days, or hospital stay. A t-test, Mann-Whitney U-test and two-tailed Fisher's exact test were used to compare patients with and without PPCs. p-values <0.05 were considered statistically significant. Results Of 398 patients, PPC developed in 64 (16%). Patients with PPCs more frequently underwent lobectomy by open thoracotomy, had longer hospital and ICU length of stay and higher 30-and 90-day mortality. Moreover, patients with PPCs exhibited a higher V'E/V'CO2 ratio both at rest and peak exercise. Both ratios were independently associated with PPCs. At rest, the contribution of PaCO2 and VD/VT to the increase in V'E/V'CO2 ratio in patients with PPCs was 45% and 55%, respectively. At peak exercise, the contribution of PaCO2 and VD/VT to the increase in V'E/V'CO2 ratio was 16% and 84%, respectively. Conclusions VD/VT (V'/Q' mismatch and/or rapid shallow breathing pattern) is the dominant contributor to the increase in V'E/V'CO2 in lung resection candidates who develop PPCs.Methods: Consecutive lung resection candidates from two prior prospective studies were included inthis post-hoc analysis. All subjects underwent preoperative spirometry, cardiopulmonary exercisetesting and arterial blood gas analysis at rest and peak exercise. PPC were prospectively assessedduring the first 30 post-operative days, or hospital stay. Student t-test, Mann-Whitney U test and two-tailed Fisher exact test were used to compare patients with and without PPC. P values <0.05 wereconsidered statistically significant.Results: Of 398 patients, PPC developed in 64 (16%). Patients with PPC more frequently underwentlobectomy by open thoracotomy, had longer hospital and ICU length of stay and higher 30- and 90-day mortality. Moreover, patients with PPC exhibited higher VE/VCO2 ratio both at rest and peakexercise. Both ratios were independently associated with PPC. At rest, the contribution of PaCO2 andVD/VT to the increase in VE/VCO2 ratio in patients with PPC was 45% and 55%, respectively. At peakexercise, the contribution of PaCO2 and VD/VT to the increase in VE/VCO2 ratio was 16% and 84 %,respectively
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
30203 - Respiratory systems
Návaznosti výsledku
Projekt
<a href="/cs/project/NU21-06-00086" target="_blank" >NU21-06-00086: Trénink dechových svalů jako způsob pre-habilitace před plicním resekčním zákrokem</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2025
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
ERJ Open Research
ISSN
2312-0541
e-ISSN
2312-0541
Svazek periodika
11
Číslo periodika v rámci svazku
2
Stát vydavatele periodika
GB - Spojené království Velké Británie a Severního Irska
Počet stran výsledku
9
Strana od-do
007922024
Kód UT WoS článku
001477535300001
EID výsledku v databázi Scopus
2-s2.0-105001867280