Reduction of Ultra-High-Frequency ECG Components Following Sodium Channel Blockade by Propafenone: Evidence for Their Electrophysiological Origin

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F25%3A00082543" target="_blank" >RIV/00159816:_____/25:00082543 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.22489/CinC.2025.277" target="_blank" >http://dx.doi.org/10.22489/CinC.2025.277</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.22489/CinC.2025.277" target="_blank" >10.22489/CinC.2025.277</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Reduction of Ultra-High-Frequency ECG Components Following Sodium Channel Blockade by Propafenone: Evidence for Their Electrophysiological Origin

Popis výsledku v původním jazyce

Background: Ultra-high-frequency (UHF) ECG is a non-invasive method for assessing ventricular electrical dyssynchrony. The origin of UHF components in ECG remains uncertain. It has been hypothesized that UHF components arise from rapid changes in membrane voltage during sodium channel opening. This study aimed to evaluate changes in UHF components after the administration of propafenone, a sodium channel blocker. Method: We analyzed data from 12 patients. For each patient, amplitude envelopes from 8 precordial leads (V1-V8) were analyzed across 76 frequency bands ranging from 150 to 1000 Hz. For each lead and frequency band, the ratio of the maximum and the area of envelopes before and after propafenone administration was calculated and subsequently averaged across frequency bands as well as leads. Results: Our results show that 11 out of 12 patients exhibited a reduction in the UHF component following sodium channel blockade. The median ratios before versus after propafenone administration were 1.51 and 1.29 for amplitude envelope maximum and area, respectively (p &lt; 0.01). Conclusion: This study supports the hypothesis that the UHF components in the ECG are caused by the rapid opening of sodium channels. (C) 2025 IEEE Computer Society. All rights reserved.

Název v anglickém jazyce

Reduction of Ultra-High-Frequency ECG Components Following Sodium Channel Blockade by Propafenone: Evidence for Their Electrophysiological Origin

Popis výsledku anglicky

Background: Ultra-high-frequency (UHF) ECG is a non-invasive method for assessing ventricular electrical dyssynchrony. The origin of UHF components in ECG remains uncertain. It has been hypothesized that UHF components arise from rapid changes in membrane voltage during sodium channel opening. This study aimed to evaluate changes in UHF components after the administration of propafenone, a sodium channel blocker. Method: We analyzed data from 12 patients. For each patient, amplitude envelopes from 8 precordial leads (V1-V8) were analyzed across 76 frequency bands ranging from 150 to 1000 Hz. For each lead and frequency band, the ratio of the maximum and the area of envelopes before and after propafenone administration was calculated and subsequently averaged across frequency bands as well as leads. Results: Our results show that 11 out of 12 patients exhibited a reduction in the UHF component following sodium channel blockade. The median ratios before versus after propafenone administration were 1.51 and 1.29 for amplitude envelope maximum and area, respectively (p &lt; 0.01). Conclusion: This study supports the hypothesis that the UHF components in the ECG are caused by the rapid opening of sodium channels. (C) 2025 IEEE Computer Society. All rights reserved.

Druh

D - Stať ve sborníku

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Computing in Cardiology

ISBN

—

ISSN

2325-8861

e-ISSN

—

Počet stran výsledku

4

Strana od-do

"neuvedeno"

Název nakladatele

Computing in Cardiology

Místo vydání

—

Místo konání akce

Sao Paulo

Datum konání akce

14. 9. 2025

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

—