Development of Improved Dosimetry Standards for FLASH Radiotherapy: The UHDpulse Project

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00177016%3A_____%2F22%3AN0000122" target="_blank" >RIV/00177016:_____/22:N0000122 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.13182/ICRSRPSD22-39191" target="_blank" >http://dx.doi.org/10.13182/ICRSRPSD22-39191</a>

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Development of Improved Dosimetry Standards for FLASH Radiotherapy: The UHDpulse Project

Popis výsledku v původním jazyce

FLASH radiotherapy (FLASH-RT) is a modern and promising cancer treatment modality still in its early stages of development and application. The prescribed dose is delivered in few radiation pulses of ultra-high dose rate [1]. This irradiation protocol has been proven to significantly reduce adverse side effects to healthy tissues while being as effective for tumor control as conventional radiotherapy [1-5]. Therefore, it is possible to mitigate dramatically adverse reactions to aggressive radiation therapies even with limited geometrical conformity, and to extend the prescribed dose to unprecedented tumor control (Fig. 1).The sparing effectiveness of FLASH-RT is observed using photons [4] as well as protons [6] beams, but it the majority of the pre-clinical studies have been conducted using electron beams [7, 8]. Unfortunately, clinical electron beams range from 5–50 MeV in energy and are not suitable for treatment of deep-seated tumors (>10 cm). FLASH-RT for deep-seated could be attained with very high energy electron (VHEE) [9] beams which, on their side, require long and bulky accelerators for their production. Laser-driven accelerators are seen as a compact and cost-effective accelerators for radiotherapy for VHEE [10, 11]. As well as with protons [12]. In fact, laser-driven accelerators can, deliver ultra-short radiation pulses of extremely high dose rate (up to 109 – 1012 Gy/s).

Název v anglickém jazyce

Development of Improved Dosimetry Standards for FLASH Radiotherapy: The UHDpulse Project

Popis výsledku anglicky

FLASH radiotherapy (FLASH-RT) is a modern and promising cancer treatment modality still in its early stages of development and application. The prescribed dose is delivered in few radiation pulses of ultra-high dose rate [1]. This irradiation protocol has been proven to significantly reduce adverse side effects to healthy tissues while being as effective for tumor control as conventional radiotherapy [1-5]. Therefore, it is possible to mitigate dramatically adverse reactions to aggressive radiation therapies even with limited geometrical conformity, and to extend the prescribed dose to unprecedented tumor control (Fig. 1).The sparing effectiveness of FLASH-RT is observed using photons [4] as well as protons [6] beams, but it the majority of the pre-clinical studies have been conducted using electron beams [7, 8]. Unfortunately, clinical electron beams range from 5–50 MeV in energy and are not suitable for treatment of deep-seated tumors (>10 cm). FLASH-RT for deep-seated could be attained with very high energy electron (VHEE) [9] beams which, on their side, require long and bulky accelerators for their production. Laser-driven accelerators are seen as a compact and cost-effective accelerators for radiotherapy for VHEE [10, 11]. As well as with protons [12]. In fact, laser-driven accelerators can, deliver ultra-short radiation pulses of extremely high dose rate (up to 109 – 1012 Gy/s).

Druh

O - Ostatní výsledky

CEP obor

—

OECD FORD obor

10304 - Nuclear physics

Projekt

<a href="/cs/project/8B19001" target="_blank" >8B19001: Metrology for advanced radiotherapy using particle beams with ultra-high pulse dose rates</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů