Radiobiology experiments with ultra-high dose rate laser-driven protons: methodology and state-of-the-art

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F21%3A00547183" target="_blank" >RIV/68378271:_____/21:00547183 - isvavai.cz</a>

Výsledek na webu

<a href="http://hdl.handle.net/11104/0323523" target="_blank" >http://hdl.handle.net/11104/0323523</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fphy.2021.624963" target="_blank" >10.3389/fphy.2021.624963</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Radiobiology experiments with ultra-high dose rate laser-driven protons: methodology and state-of-the-art

Popis výsledku v původním jazyce

The use of particle accelerators in radiotherapy has significantly changed the therapeutic outcomes for many types of solid tumours. In particular, protons are well known for sparing normal tissues and increasing the overall therapeutic index. Recent studies show that normal tissue sparing can be further enhanced through proton delivery at 100 Gy/s and above, in the so-called FLASH regime. This has generated very significant interest in assessing the biological effects of proton pulses delivered at very high dose rates. Laser-accelerated proton beams have unique temporal emission properties, which can be exploited to deliver Gy level doses in single or multiple pulses at dose rates exceeding by many orders of magnitude those currently used in FLASH approaches. An extensive investigation of the radiobiology of laser-driven protons is therefore not only necessary for future clinical application, but also offers the opportunity of accessing yet untested regimes of radiobiology.

Název v anglickém jazyce

Radiobiology experiments with ultra-high dose rate laser-driven protons: methodology and state-of-the-art

Popis výsledku anglicky

The use of particle accelerators in radiotherapy has significantly changed the therapeutic outcomes for many types of solid tumours. In particular, protons are well known for sparing normal tissues and increasing the overall therapeutic index. Recent studies show that normal tissue sparing can be further enhanced through proton delivery at 100 Gy/s and above, in the so-called FLASH regime. This has generated very significant interest in assessing the biological effects of proton pulses delivered at very high dose rates. Laser-accelerated proton beams have unique temporal emission properties, which can be exploited to deliver Gy level doses in single or multiple pulses at dose rates exceeding by many orders of magnitude those currently used in FLASH approaches. An extensive investigation of the radiobiology of laser-driven protons is therefore not only necessary for future clinical application, but also offers the opportunity of accessing yet untested regimes of radiobiology.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10305 - Fluids and plasma physics (including surface physics)

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Frontiers in Physics

ISSN

2296-424X

e-ISSN

2296-424X

Svazek periodika

9

Číslo periodika v rámci svazku

Apr

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

12

Strana od-do

624963

Kód UT WoS článku

000642239200001

EID výsledku v databázi Scopus

2-s2.0-85104594063