Paraganglioma-like medullary thyroid carcinoma: fine needle aspiration cytology features with histological correlation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F09%3A00201709" target="_blank" >RIV/00179906:_____/09:00201709 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11150/09:00208713 RIV/00023761:_____/09:#0000367

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Paraganglioma-like medullary thyroid carcinoma: fine needle aspiration cytology features with histological correlation

Popis výsledku v původním jazyce

Two cases of an extremely rare paraganglioma-like variant of medullary thyroid carcinoma(MTC) are reported.The cytological smears contained predominantly ovoid to spindled epithelial cells arranged in cohesive three-dimensional clusters with sharp margins; isolated individual cells were rare.No colloid or amyloid was present in the background. Tumour cells showed significant nuclear atypia with occasional bizarre and binucleated cells. Their chromatin was coarse, granular, sometimes with grooves and intranuclear inclusions. Calcitonin was demonstrated in case 2. Histology confirmed paraganglioma variant of MTC in both cases. Mutation of RET proto-oncogene in exon 16 (Met918Thr) - germline in case 2 and somatic in case 1 was detected by DNA sequencing in both cases.This is the first report of cytological findings in the paraganglioma-like variant of MTC. Despite its rarity, it can be reliably diagnosed by FNAC.

Název v anglickém jazyce

Paraganglioma-like medullary thyroid carcinoma: fine needle aspiration cytology features with histological correlation

Popis výsledku anglicky

Two cases of an extremely rare paraganglioma-like variant of medullary thyroid carcinoma(MTC) are reported.The cytological smears contained predominantly ovoid to spindled epithelial cells arranged in cohesive three-dimensional clusters with sharp margins; isolated individual cells were rare.No colloid or amyloid was present in the background. Tumour cells showed significant nuclear atypia with occasional bizarre and binucleated cells. Their chromatin was coarse, granular, sometimes with grooves and intranuclear inclusions. Calcitonin was demonstrated in case 2. Histology confirmed paraganglioma variant of MTC in both cases. Mutation of RET proto-oncogene in exon 16 (Met918Thr) - germline in case 2 and somatic in case 1 was detected by DNA sequencing in both cases.This is the first report of cytological findings in the paraganglioma-like variant of MTC. Despite its rarity, it can be reliably diagnosed by FNAC.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

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Projekt

<a href="/cs/project/NR9165" target="_blank" >NR9165: Hlavní genetické příčiny a modifikující faktory v patogenezi nádorů štítné žlázy</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Cytopathology

ISSN

0956-5507

e-ISSN

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Svazek periodika

20

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

7

Strana od-do

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Kód UT WoS článku

000266015500007

EID výsledku v databázi Scopus

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