Chemoresistance testing of human ovarian cancer cells and its in vitro model

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F10%3A10081786" target="_blank" >RIV/00179906:_____/10:10081786 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11150/10:10081786

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Chemoresistance testing of human ovarian cancer cells and its in vitro model

Popis výsledku v původním jazyce

Ovarian carcinoma represents the most common cause of death from gynecological malignancies in Europe and North America. The standard chemotherapeutical regimen involves the administration of platinum derivate, in advanced stage with paclitaxel. Chemoresistance testing of ovarian tumour cells may help to choose optimal chemotherapeutic drug. One of approaches of individualization of chemotherapy is in vitro chemosensitivity testing. In our study, we evaluated the cytotoxic effects of selected chemotherapeutics in cells isolated from ovarian tumours and ascites of patients. The highest sensitivity showed cells to topotecan, sensitivity to cisplatin was higher than to carboplatin and paclitaxel showed most often only the marginal reactivity. The same test was done on cells that have been frozen for several weeks. Moreover, chemosensitivity of cells isolated from solid tumour and ascites from the same patient did not show any significant difference with exaption of paclitaxel.

Název v anglickém jazyce

Chemoresistance testing of human ovarian cancer cells and its in vitro model

Popis výsledku anglicky

Ovarian carcinoma represents the most common cause of death from gynecological malignancies in Europe and North America. The standard chemotherapeutical regimen involves the administration of platinum derivate, in advanced stage with paclitaxel. Chemoresistance testing of ovarian tumour cells may help to choose optimal chemotherapeutic drug. One of approaches of individualization of chemotherapy is in vitro chemosensitivity testing. In our study, we evaluated the cytotoxic effects of selected chemotherapeutics in cells isolated from ovarian tumours and ascites of patients. The highest sensitivity showed cells to topotecan, sensitivity to cisplatin was higher than to carboplatin and paclitaxel showed most often only the marginal reactivity. The same test was done on cells that have been frozen for several weeks. Moreover, chemosensitivity of cells isolated from solid tumour and ascites from the same patient did not show any significant difference with exaption of paclitaxel.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

—

Projekt

<a href="/cs/project/NS9737" target="_blank" >NS9737: Změny chemorezistence/chemosensitivity ovariálních nádorových buněk</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Toxicology in Vitro

ISSN

0887-2333

e-ISSN

—

Svazek periodika

24

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

8

Strana od-do

—

Kód UT WoS článku

000285124500010

EID výsledku v databázi Scopus

—