The role of atorvastatin in bone metabolism in male albino Wistar rats

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F11%3A10105847" target="_blank" >RIV/00179906:_____/11:10105847 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60162694:G44__/11:00002527 RIV/00216208:11150/11:10105847

Výsledek na webu

<a href="http://dx.doi.org/10.1691/ph.2011.1525" target="_blank" >http://dx.doi.org/10.1691/ph.2011.1525</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1691/ph.2011.1525" target="_blank" >10.1691/ph.2011.1525</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The role of atorvastatin in bone metabolism in male albino Wistar rats

Popis výsledku v původním jazyce

The aim of experiment was to follow the effect of atorvastatin on bone metabolism in male rats. Our study was carried out on 16 rats. The control group (CO) was given aqua pro injectione (0.2 mL/100 g BW; gavage) and the experimental group atorvastatin suspension (AT; 0.3mg in 0.2mL aqua pro inj./100 g BW; gavage) for 8 weeks. We examined serum markers of bone turnover using ELISA - C-terminal crosslinking telopeptide of type I collagen, osteocalcin, procollagen type I N propeptide and bone alkaline phosphatase (BALP). We investigated bone morphogenetic protein-2 (BMP-2) in the proximal tibia using Western blot analysis. We measured bone mineral density. The femurs were used for a biomechanical testing. After 8 weeks of atorvastatin administration, a significant decrease was found in serum level of BALP to 30% vs. CO (p = 0.005). The expression of BMP-2 was increased. Atorvastatin influenced bone metabolism by decreasing BALP, and probably in consequence increasing expression of BMP-2 in rats.

Název v anglickém jazyce

The role of atorvastatin in bone metabolism in male albino Wistar rats

Popis výsledku anglicky

The aim of experiment was to follow the effect of atorvastatin on bone metabolism in male rats. Our study was carried out on 16 rats. The control group (CO) was given aqua pro injectione (0.2 mL/100 g BW; gavage) and the experimental group atorvastatin suspension (AT; 0.3mg in 0.2mL aqua pro inj./100 g BW; gavage) for 8 weeks. We examined serum markers of bone turnover using ELISA - C-terminal crosslinking telopeptide of type I collagen, osteocalcin, procollagen type I N propeptide and bone alkaline phosphatase (BALP). We investigated bone morphogenetic protein-2 (BMP-2) in the proximal tibia using Western blot analysis. We measured bone mineral density. The femurs were used for a biomechanical testing. After 8 weeks of atorvastatin administration, a significant decrease was found in serum level of BALP to 30% vs. CO (p = 0.005). The expression of BMP-2 was increased. Atorvastatin influenced bone metabolism by decreasing BALP, and probably in consequence increasing expression of BMP-2 in rats.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

—

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Pharmazie

ISSN

0031-7144

e-ISSN

—

Svazek periodika

66

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

5

Strana od-do

606-610

Kód UT WoS článku

000294083100010

EID výsledku v databázi Scopus

2-s2.0-80053302438