Microheterogeneity of some serum glycoproteins in neurodegenerative diseases

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F12%3A10108107" target="_blank" >RIV/00179906:_____/12:10108107 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11150/12:10108107

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/S0022510X11006587" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0022510X11006587</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jns.2011.11.006" target="_blank" >10.1016/j.jns.2011.11.006</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Microheterogeneity of some serum glycoproteins in neurodegenerative diseases

Popis výsledku v původním jazyce

Protein polymorphism and aberrant protein glycosylation may play important roles in human disorders, including neurodegenerative diseases. The aim of the study was to examine possible involvement of protein genetic variants and degree of glycosylation ofsome serum glycoproteins in the manifestation of neurodegenerative disorders in a Czech population sample. Apolipoprotein (Apo) E and three main serum markers of glycosylation defects (transferrin, Tf, alpha1-antitrypsin, aAT and ApoCIII) in patients with Alzheimer's dementia (AD), Parkinson disease (PD) and vascular dementia (n=62, 139 and 44, respectively) were analyzed by isoelectric focusing. Children with serious neurological symptoms (n=55) and three age-matched control groups (n=45, 45 and 42) were examined for comparison. Of the supposedly pathognomonic protein variants Tf C2, aAT ZM and ApoE e4 only the latter was detected with higher frequency in AD patients; significant synergy of the C2/e4 allelic combination was not confir

Název v anglickém jazyce

Microheterogeneity of some serum glycoproteins in neurodegenerative diseases

Popis výsledku anglicky

Protein polymorphism and aberrant protein glycosylation may play important roles in human disorders, including neurodegenerative diseases. The aim of the study was to examine possible involvement of protein genetic variants and degree of glycosylation ofsome serum glycoproteins in the manifestation of neurodegenerative disorders in a Czech population sample. Apolipoprotein (Apo) E and three main serum markers of glycosylation defects (transferrin, Tf, alpha1-antitrypsin, aAT and ApoCIII) in patients with Alzheimer's dementia (AD), Parkinson disease (PD) and vascular dementia (n=62, 139 and 44, respectively) were analyzed by isoelectric focusing. Children with serious neurological symptoms (n=55) and three age-matched control groups (n=45, 45 and 42) were examined for comparison. Of the supposedly pathognomonic protein variants Tf C2, aAT ZM and ApoE e4 only the latter was detected with higher frequency in AD patients; significant synergy of the C2/e4 allelic combination was not confir

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FG - Pediatrie

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of the Neurological Sciences

ISSN

0022-510X

e-ISSN

—

Svazek periodika

314

Číslo periodika v rámci svazku

1-2

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

6

Strana od-do

20-25

Kód UT WoS článku

000301273000004

EID výsledku v databázi Scopus

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