Irradiated stem cells and ageing of the haematopoietic system
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F12%3A10124870" target="_blank" >RIV/00179906:_____/12:10124870 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/68081707:_____/12:00390349 RIV/60162694:G44__/12:43874674 RIV/00216208:11150/12:10124870
Výsledek na webu
<a href="http://link.springer.com/article/10.1007%2Fs00411-012-0401-5" target="_blank" >http://link.springer.com/article/10.1007%2Fs00411-012-0401-5</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00411-012-0401-5" target="_blank" >10.1007/s00411-012-0401-5</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Irradiated stem cells and ageing of the haematopoietic system
Popis výsledku v původním jazyce
In the work presented here, changes in haematopoiesis of mice (B6129SF2/J) were studied 1 year after their whole-body exposure to a dose of 7 Gy (72% of mice survived). The irradiated mice were compared with non-irradiated younger (4 months of age) and older (16 months of age) mice. There was a significant increase in the relative abundance of primitive stem cells with long-term capability of the haematopoiesis recovery lin(-)/Sca-1(+)/CD117(+)/CD34(-) in the bone marrow of mice aged 16 months (irradiated and non-irradiated) compared with those aged 4 months. In terms of the ability to respond to further whole-body irradiation at a dose of 1 Gy, the presence of gamma H2A.X foci was studied in lin(-) bone marrow cells. There was a considerable number ofpersisting foci in lin(-) stem cells isolated from the bone marrow of the older irradiated mice. In the blood count from the peripheral blood of the older mice (both non-irradiated and irradiated at 7 Gy), there was a significant increas
Název v anglickém jazyce
Irradiated stem cells and ageing of the haematopoietic system
Popis výsledku anglicky
In the work presented here, changes in haematopoiesis of mice (B6129SF2/J) were studied 1 year after their whole-body exposure to a dose of 7 Gy (72% of mice survived). The irradiated mice were compared with non-irradiated younger (4 months of age) and older (16 months of age) mice. There was a significant increase in the relative abundance of primitive stem cells with long-term capability of the haematopoiesis recovery lin(-)/Sca-1(+)/CD117(+)/CD34(-) in the bone marrow of mice aged 16 months (irradiated and non-irradiated) compared with those aged 4 months. In terms of the ability to respond to further whole-body irradiation at a dose of 1 Gy, the presence of gamma H2A.X foci was studied in lin(-) bone marrow cells. There was a considerable number ofpersisting foci in lin(-) stem cells isolated from the bone marrow of the older irradiated mice. In the blood count from the peripheral blood of the older mice (both non-irradiated and irradiated at 7 Gy), there was a significant increas
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
EB - Genetika a molekulární biologie
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/OVUOFVZ200806" target="_blank" >OVUOFVZ200806: RONSDOZ - Neinvazivní stanovení prozánětlivých ukazatelů oxidačního stresu u ozářených jako indikátor obdržené dávky záření. Ochranný efekt acetyl-L-karnitinu</a><br>
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2012
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Radiation and Environmental Biophysics
ISSN
0301-634X
e-ISSN
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Svazek periodika
51
Číslo periodika v rámci svazku
2
Stát vydavatele periodika
DE - Spolková republika Německo
Počet stran výsledku
9
Strana od-do
205-213
Kód UT WoS článku
000303464400010
EID výsledku v databázi Scopus
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