The peripheral chimerism of bone marrow-derived stem cells after transplantation: regeneration of gastrointestinal tissues in lethally irradiated mice

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F14%3A10159523" target="_blank" >RIV/00179906:_____/14:10159523 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60162694:G44__/14:43875125 RIV/00216208:11150/14:10159523

Výsledek na webu

<a href="http://onlinelibrary.wiley.com/doi/10.1111/jcmm.12227/abstract;jsessionid=39157A27811986B8B96ABE38789CAC66.f03t02" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1111/jcmm.12227/abstract;jsessionid=39157A27811986B8B96ABE38789CAC66.f03t02</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/jcmm.12227" target="_blank" >10.1111/jcmm.12227</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The peripheral chimerism of bone marrow-derived stem cells after transplantation: regeneration of gastrointestinal tissues in lethally irradiated mice

Popis výsledku v původním jazyce

Bone marrow-derived cells represent a heterogeneous cell population containing haematopoietic stem and progenitor cells. These cells have been identified as potential candidates for use in cell therapy for the regeneration of damaged tissues caused by trauma, degenerative diseases, ischaemia and inflammation or cancer treatment. In our study, we examined a model using whole-body irradiation and the transplantation of bone marrow (BM) or haematopoietic stem cells (HSCs) to study the repair of haematopoiesis, extramedullary haematopoiesis and the migration of green fluorescent protein (GFP(+)) transplanted cells into non-haematopoietic tissues. We investigated the repair of damage to the BM, peripheral blood, spleen and thymus and assessed the ability ofthis treatment to induce the entry of BM cells or GFP(+)lin(-)Sca-1(+) cells into non-haematopoietic tissues. The transplantation of BM cells or GFP(+)lin(-)Sca-1(+) cells from GFP transgenic mice successfully repopulated haematopoiesis

Název v anglickém jazyce

The peripheral chimerism of bone marrow-derived stem cells after transplantation: regeneration of gastrointestinal tissues in lethally irradiated mice

Popis výsledku anglicky

Bone marrow-derived cells represent a heterogeneous cell population containing haematopoietic stem and progenitor cells. These cells have been identified as potential candidates for use in cell therapy for the regeneration of damaged tissues caused by trauma, degenerative diseases, ischaemia and inflammation or cancer treatment. In our study, we examined a model using whole-body irradiation and the transplantation of bone marrow (BM) or haematopoietic stem cells (HSCs) to study the repair of haematopoiesis, extramedullary haematopoiesis and the migration of green fluorescent protein (GFP(+)) transplanted cells into non-haematopoietic tissues. We investigated the repair of damage to the BM, peripheral blood, spleen and thymus and assessed the ability ofthis treatment to induce the entry of BM cells or GFP(+)lin(-)Sca-1(+) cells into non-haematopoietic tissues. The transplantation of BM cells or GFP(+)lin(-)Sca-1(+) cells from GFP transgenic mice successfully repopulated haematopoiesis

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

<a href="/cs/project/NT13477" target="_blank" >NT13477: Užití syntetických biomateriálů k léčení rozsáhlých defektů skeletu při reimplantaci totální endoprotézy kyčelního kloubu</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Cellular and Molecular Medicine [online]

ISSN

1582-4934

e-ISSN

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Svazek periodika

18

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

12

Strana od-do

832-843

Kód UT WoS článku

000335861500009

EID výsledku v databázi Scopus

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