Biologic importance and prognostic significance of selected clinicopathological parameters in patients with oral and oropharyngeal squamous cell carcinoma, with emphasis on smoking, protein p16INK4a expression, and HPV status

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F12%3A10125027" target="_blank" >RIV/00179906:_____/12:10125027 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11150/12:10125027

Výsledek na webu

<a href="http://www.elis.sk/index.php?page=shop.product_details&flypage=flypage.tpl&product_id=2822&category_id=87&option=com_virtuemart&vmcchk=1&Itemid=1" target="_blank" >http://www.elis.sk/index.php?page=shop.product_details&flypage=flypage.tpl&product_id=2822&category_id=87&option=com_virtuemart&vmcchk=1&Itemid=1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4149/neo_2012_052" target="_blank" >10.4149/neo_2012_052</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Biologic importance and prognostic significance of selected clinicopathological parameters in patients with oral and oropharyngeal squamous cell carcinoma, with emphasis on smoking, protein p16INK4a expression, and HPV status

Popis výsledku v původním jazyce

The aim of the study is to evaluate biologic importance and prognostic significance of selected clinicopathological parameters in patients with oral (OSCC) and oropharyngeal (OPSCC) squamous cell carcinoma, with emphasis on smoking, protein p16 expression and HPV status. The study sample consisted of 48 patients with OSCC and 44 patients with OPSCC. Half of the patients were nonsmokers. p16 expression was detected in 17/48 OSCCs and in 36/44 OPSCCs and HPV DNA was present in 7/48 OSCCs and in 35/44 OPSCCs. OPSCCs were more frequently basaloid (p < 0.001) while OSCCs were more frequently conventional (p < 0.000001). OSCCs were more likely to recur locally and to be the cause of death (p = 0.009). HPV-positive tumors were more frequently localized in oropharynx, were basaloid SCCs and were p16- and HPV-positive (p < 0.000001). HPV-negative tumors were more frequently localized in oral cavity (p < 0.000001), more frequently associated with locoregional recurrence (p = 0.030) and with tumo

Název v anglickém jazyce

Biologic importance and prognostic significance of selected clinicopathological parameters in patients with oral and oropharyngeal squamous cell carcinoma, with emphasis on smoking, protein p16INK4a expression, and HPV status

Popis výsledku anglicky

The aim of the study is to evaluate biologic importance and prognostic significance of selected clinicopathological parameters in patients with oral (OSCC) and oropharyngeal (OPSCC) squamous cell carcinoma, with emphasis on smoking, protein p16 expression and HPV status. The study sample consisted of 48 patients with OSCC and 44 patients with OPSCC. Half of the patients were nonsmokers. p16 expression was detected in 17/48 OSCCs and in 36/44 OPSCCs and HPV DNA was present in 7/48 OSCCs and in 35/44 OPSCCs. OPSCCs were more frequently basaloid (p < 0.001) while OSCCs were more frequently conventional (p < 0.000001). OSCCs were more likely to recur locally and to be the cause of death (p = 0.009). HPV-positive tumors were more frequently localized in oropharynx, were basaloid SCCs and were p16- and HPV-positive (p < 0.000001). HPV-negative tumors were more frequently localized in oral cavity (p < 0.000001), more frequently associated with locoregional recurrence (p = 0.030) and with tumo

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Neoplasma

ISSN

0028-2685

e-ISSN

—

Svazek periodika

59

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

SK - Slovenská republika

Počet stran výsledku

11

Strana od-do

398-408

Kód UT WoS článku

000305499900007

EID výsledku v databázi Scopus

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