The role of high-risk human papillomavirus infection in oral and oropharyngeal squamous cell carcinoma in non-smoking and non-drinking patients: a clinicopathological and molecular study of 46 cases
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F11%3A10105993" target="_blank" >RIV/00216208:11150/11:10105993 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00179906:_____/11:10105993
Výsledek na webu
<a href="http://www.ncbi.nlm.nih.gov/pubmed/21221634" target="_blank" >http://www.ncbi.nlm.nih.gov/pubmed/21221634</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00428-010-1037-y" target="_blank" >10.1007/s00428-010-1037-y</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
The role of high-risk human papillomavirus infection in oral and oropharyngeal squamous cell carcinoma in non-smoking and non-drinking patients: a clinicopathological and molecular study of 46 cases
Popis výsledku v původním jazyce
The aim of the study was to investigate the role of high-risk human papillomavirus (HR-HPV) infection in the etiopathogenesis of oral (OSCC) and oropharyngeal (OPSCC) squamous cell carcinoma in non-smoking and non-drinking patients (NSNDP). Twenty-four OSCCs and 22 OPSCCs were analyzed by immunohistochemistry for p16INK4a protein (p16) expression and by chromogene in situ hybridization (CISH) and polymerase chain reaction (PCR) for HR-HPV DNA presence. The series included 23 males and 23 females aged 35-93 years. p16 expression was seen in 7/24 (29%) OSCCs and in 22/22 (100%) OPSCCs. Using CISH, HR-HPV DNA was observed in 6/24 (25%) OSCCs and in 21/22 (95%) OPSCCs. HPV DNA was found in 3/24 (13%) OSCCs and in 18/22 (82%) OPSCCs using PCR. HPV 16 and 33were detected in 16 and in 2 cases, respectively. Compared with OSCCs, OPSCCs more frequently showed basaloid morphology (p { 0.0001), lymph node involvement (p = 0.0063), diffuse p16 expression (p { 0.0001), HR-HPV DNA presence using bo
Název v anglickém jazyce
The role of high-risk human papillomavirus infection in oral and oropharyngeal squamous cell carcinoma in non-smoking and non-drinking patients: a clinicopathological and molecular study of 46 cases
Popis výsledku anglicky
The aim of the study was to investigate the role of high-risk human papillomavirus (HR-HPV) infection in the etiopathogenesis of oral (OSCC) and oropharyngeal (OPSCC) squamous cell carcinoma in non-smoking and non-drinking patients (NSNDP). Twenty-four OSCCs and 22 OPSCCs were analyzed by immunohistochemistry for p16INK4a protein (p16) expression and by chromogene in situ hybridization (CISH) and polymerase chain reaction (PCR) for HR-HPV DNA presence. The series included 23 males and 23 females aged 35-93 years. p16 expression was seen in 7/24 (29%) OSCCs and in 22/22 (100%) OPSCCs. Using CISH, HR-HPV DNA was observed in 6/24 (25%) OSCCs and in 21/22 (95%) OPSCCs. HPV DNA was found in 3/24 (13%) OSCCs and in 18/22 (82%) OPSCCs using PCR. HPV 16 and 33were detected in 16 and in 2 cases, respectively. Compared with OSCCs, OPSCCs more frequently showed basaloid morphology (p { 0.0001), lymph node involvement (p = 0.0063), diffuse p16 expression (p { 0.0001), HR-HPV DNA presence using bo
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FP - Ostatní lékařské obory
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2011
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Virchows Archiv : an international journal of pathology
ISSN
0945-6317
e-ISSN
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Svazek periodika
458
Číslo periodika v rámci svazku
2
Stát vydavatele periodika
DE - Spolková republika Německo
Počet stran výsledku
9
Strana od-do
179-187
Kód UT WoS článku
000286830000008
EID výsledku v databázi Scopus
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