Identification of MicroRNAs associated with early relapse after nephrectomy in renal cell carcinoma patients

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F12%3A10125074" target="_blank" >RIV/00179906:_____/12:10125074 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14740/12:00060119 RIV/00216208:11150/12:10125074 RIV/00209805:_____/12:#0000373

Výsledek na webu

<a href="http://onlinelibrary.wiley.com/doi/10.1002/gcc.21957/pdf" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1002/gcc.21957/pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/gcc.21957" target="_blank" >10.1002/gcc.21957</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Identification of MicroRNAs associated with early relapse after nephrectomy in renal cell carcinoma patients

Popis výsledku v původním jazyce

Renal cell carcinoma (RCC) is the most common neoplasm of adult kidney. One of the important unmet medical needs in RCC is prognostic biomarker enabling identification of patients at high risk of relapse after nephrectomy. MicroRNAs (miRNAs) constitute arobust regulatory network with posttranscriptional regulatory efficiency for almost one-half of human coding genes, including oncogenes and tumor suppressors. To identify potential prognostic miRNAs, we analyzed expression profiles in tumors of different prognostic groups of RCC patients. Seventy-seven patients with clear cell RCC and detailed clinicopathological data were enrolled in a single-center study. Global miRNA expression profiles were obtained by use of TaqMan Low Density Arrays (754 parallelquantitative reverse-transcriptase polymerase chain reactions (qRT-PCR) reactions). For validation of identified miRNAs individual miRNA TaqMan assays were performed in an independent group of patients. We identified tumor relapse-signat

Název v anglickém jazyce

Identification of MicroRNAs associated with early relapse after nephrectomy in renal cell carcinoma patients

Popis výsledku anglicky

Renal cell carcinoma (RCC) is the most common neoplasm of adult kidney. One of the important unmet medical needs in RCC is prognostic biomarker enabling identification of patients at high risk of relapse after nephrectomy. MicroRNAs (miRNAs) constitute arobust regulatory network with posttranscriptional regulatory efficiency for almost one-half of human coding genes, including oncogenes and tumor suppressors. To identify potential prognostic miRNAs, we analyzed expression profiles in tumors of different prognostic groups of RCC patients. Seventy-seven patients with clear cell RCC and detailed clinicopathological data were enrolled in a single-center study. Global miRNA expression profiles were obtained by use of TaqMan Low Density Arrays (754 parallelquantitative reverse-transcriptase polymerase chain reactions (qRT-PCR) reactions). For validation of identified miRNAs individual miRNA TaqMan assays were performed in an independent group of patients. We identified tumor relapse-signat

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

—

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Genes Chromosomes and Cancer

ISSN

1045-2257

e-ISSN

—

Svazek periodika

51

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

707-716

Kód UT WoS článku

000303762500008

EID výsledku v databázi Scopus

—