Contribution to investigation of antimicrobial activity of styrylquinolines

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F12%3A10133745" target="_blank" >RIV/00179906:_____/12:10133745 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11150/12:10133745 RIV/62157124:16370/12:43871087

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.bmc.2012.10.027" target="_blank" >http://dx.doi.org/10.1016/j.bmc.2012.10.027</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.bmc.2012.10.027" target="_blank" >10.1016/j.bmc.2012.10.027</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Contribution to investigation of antimicrobial activity of styrylquinolines

Popis výsledku v původním jazyce

Series of new ring-substituted styrylquinolines and two oxorhenium complexes were prepared and characterized. The compounds were analyzed using RP-HPLC to determine lipophilicity. Primary in vitro screening of the synthesized compounds was performed against fungal and bacterial strains. Some compounds were active against bacteria at micromolar level and against fungi at submicromolar level. Compounds 5,7-dichloro-2-[2-(2-ethoxyphenyl)vinyl]quinolin-8-ol expressed excellent antifungal activity comparablewith or higher than the standard fluconazole as well as antibacterial activity against Staphylococcus strains comparable with or higher than the standards bacitracin, penicillin and ciprofloxacin. The structure-activity relationships are discussed.

Název v anglickém jazyce

Contribution to investigation of antimicrobial activity of styrylquinolines

Popis výsledku anglicky

Series of new ring-substituted styrylquinolines and two oxorhenium complexes were prepared and characterized. The compounds were analyzed using RP-HPLC to determine lipophilicity. Primary in vitro screening of the synthesized compounds was performed against fungal and bacterial strains. Some compounds were active against bacteria at micromolar level and against fungi at submicromolar level. Compounds 5,7-dichloro-2-[2-(2-ethoxyphenyl)vinyl]quinolin-8-ol expressed excellent antifungal activity comparablewith or higher than the standard fluconazole as well as antibacterial activity against Staphylococcus strains comparable with or higher than the standards bacitracin, penicillin and ciprofloxacin. The structure-activity relationships are discussed.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EE - Mikrobiologie, virologie

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Bioorganic and Medicinal Chemistry

ISSN

0968-0896

e-ISSN

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Svazek periodika

20

Číslo periodika v rámci svazku

24

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

9

Strana od-do

6960-6968

Kód UT WoS článku

000311421300007

EID výsledku v databázi Scopus

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