In vitro antimicrobial activity of light-activated phthalocyanines

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F13%3A10189431" target="_blank" >RIV/00179906:_____/13:10189431 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11150/13:10189431

Výsledek na webu

<a href="http://dx.doi.org/10.2478/s11535-013-0118-0" target="_blank" >http://dx.doi.org/10.2478/s11535-013-0118-0</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2478/s11535-013-0118-0" target="_blank" >10.2478/s11535-013-0118-0</a>

Jazyk výsledku

angličtina

Název v původním jazyce

In vitro antimicrobial activity of light-activated phthalocyanines

Popis výsledku v původním jazyce

Background: Photodynamic antimicrobial therapy (PACT) is proposed as a topical, non-invasive approach suitable for treatment of locally occurring infection. Research of photosensitizers, (PS) as well as their development, is aimed at finding effective antimicrobial substances which would have a broad-spectrum potency. The aim of this paper is to evaluate the antimicrobial effect of phthalocyanine (Pc) derivatives. Methods: Fifteen different Pc compounds were investigated. Their photokilling activity wastested on Staphylococcus aureus, Escherichia coli and Candida albicans. After treating of microbial cells with Pc at the concentrations: 1 mg/l, 2 mg/l, 4 mg/l, 8 mg/l for 30 minutes, the cultures were irradiated with low-power laser light at a wavelength of 670 nm (20 J/cm2, 40 J/cm2). The effectiveness of photoinactivation was evaluated based on the decrease in number (log10) of viable bacteria. Results: Eight Pc compounds tested showed antibacterial effects against S. aureus, but onl

Název v anglickém jazyce

In vitro antimicrobial activity of light-activated phthalocyanines

Popis výsledku anglicky

Background: Photodynamic antimicrobial therapy (PACT) is proposed as a topical, non-invasive approach suitable for treatment of locally occurring infection. Research of photosensitizers, (PS) as well as their development, is aimed at finding effective antimicrobial substances which would have a broad-spectrum potency. The aim of this paper is to evaluate the antimicrobial effect of phthalocyanine (Pc) derivatives. Methods: Fifteen different Pc compounds were investigated. Their photokilling activity wastested on Staphylococcus aureus, Escherichia coli and Candida albicans. After treating of microbial cells with Pc at the concentrations: 1 mg/l, 2 mg/l, 4 mg/l, 8 mg/l for 30 minutes, the cultures were irradiated with low-power laser light at a wavelength of 670 nm (20 J/cm2, 40 J/cm2). The effectiveness of photoinactivation was evaluated based on the decrease in number (log10) of viable bacteria. Results: Eight Pc compounds tested showed antibacterial effects against S. aureus, but onl

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EE - Mikrobiologie, virologie

OECD FORD obor

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Projekt

<a href="/cs/project/2B06104" target="_blank" >2B06104: Fotosenzibilizátory v zubním lékařství</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Central European Journal of Biology

ISSN

1895-104X

e-ISSN

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Svazek periodika

8

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

PL - Polská republika

Počet stran výsledku

10

Strana od-do

168-177

Kód UT WoS článku

000312340500006

EID výsledku v databázi Scopus

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