Retention behavior of pyridinium oximes on PFP stationary phase in high-performance liquid chromatography

Kód výsledku v IS VaVaI

RIV/00179906:_____/14:10227211 - isvavai.cz

Nalezeny alternativní kódy

RIV/62690094:18470/14:50002315 RIV/60162694:G44__/14:43874792

Výsledek na webu

http://chromsci.oxfordjournals.org/content/52/3/246.full.pdf+html

DOI - Digital Object Identifier

10.1093/chromsci/bmt019

Jazyk výsledku

angličtina

Název v původním jazyce

Retention behavior of pyridinium oximes on PFP stationary phase in high-performance liquid chromatography

Popis výsledku v původním jazyce

The chromatographic behavior was studied of a series of potential acetylcholinesterase reactivators, pyridinium oximes, bearing linear aliphatic chains of the length of the aliphatic bridge from 1 to 12 carbon atoms, on a pentafluorophenyl-modified stationary phase. The retention mechanisms and the dependence of the capacity factor on mobile phase composition, aliphatic chain bridge length and calculated log P were evaluated and discussed in detail. The separation of the studied oximes was found to be driven by hydrophobic interactions when a lower content of organic modifier was used in mobile phase; however, the ion-exchange mechanism was the leading one when a large portion of organic modifier was used. In addition, the lipophilicity was found to bea driving mechanism of the separation of oximes bearing a connecting chain of the length of 6-12 carbon atoms, whereas the retention of oximes with shorter connecting chains was significantly influenced by other separation mechanisms suc

Název v anglickém jazyce

Retention behavior of pyridinium oximes on PFP stationary phase in high-performance liquid chromatography

Popis výsledku anglicky

The chromatographic behavior was studied of a series of potential acetylcholinesterase reactivators, pyridinium oximes, bearing linear aliphatic chains of the length of the aliphatic bridge from 1 to 12 carbon atoms, on a pentafluorophenyl-modified stationary phase. The retention mechanisms and the dependence of the capacity factor on mobile phase composition, aliphatic chain bridge length and calculated log P were evaluated and discussed in detail. The separation of the studied oximes was found to be driven by hydrophobic interactions when a lower content of organic modifier was used in mobile phase; however, the ion-exchange mechanism was the leading one when a large portion of organic modifier was used. In addition, the lipophilicity was found to bea driving mechanism of the separation of oximes bearing a connecting chain of the length of 6-12 carbon atoms, whereas the retention of oximes with shorter connecting chains was significantly influenced by other separation mechanisms suc

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CB - Analytická chemie, separace

OECD FORD obor

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Projekt

NT12062: Příprava a hodnocení účinnosti nových terapeutik proti otravám pesticidy

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Chromatographic Science

ISSN

0021-9665

e-ISSN

—

Svazek periodika

52

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

246-251

Kód UT WoS článku

000342734000009

EID výsledku v databázi Scopus

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