Deoxynivalenol: signaling pathways and human exposure risk assessment-an update

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F14%3A10282617" target="_blank" >RIV/00179906:_____/14:10282617 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/62690094:18450/14:50002606 RIV/62690094:18470/14:50002606

Výsledek na webu

<a href="http://link.springer.com/article/10.1007%2Fs00204-014-1354-z" target="_blank" >http://link.springer.com/article/10.1007%2Fs00204-014-1354-z</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00204-014-1354-z" target="_blank" >10.1007/s00204-014-1354-z</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Deoxynivalenol: signaling pathways and human exposure risk assessment-an update

Popis výsledku v původním jazyce

Deoxynivalenol (DON) is a group B trichothecene and a common contaminant of crops worldwide. This toxin is known to cause a spectrum of diseases in animals and humans such as vomiting and gastroenteritis. Importantly, DON could inhibit the synthesis of protein and nucleonic acid and induce cell apoptosis in eukaryote cells. The transduction of signaling pathways is involved in the underlying mechanism of the cytotoxicity of DON. Mitogen-activated protein kinase and Janus kinase/signal transducer and activator of transcription seem to be two important signaling pathways and induce the inflammatory response by modulating the binding activates of specific transcription factors. This review mainly discussed the toxic mechanism of DON from the vantage pointof signaling pathways and also assessed the profiles of DON and its metabolites in humans. Importantly, we conducted a human exposure risk assessment of DON from cereals, cereal-based foods, vegetables, water, and animal-derived foods in

Název v anglickém jazyce

Deoxynivalenol: signaling pathways and human exposure risk assessment-an update

Popis výsledku anglicky

Deoxynivalenol (DON) is a group B trichothecene and a common contaminant of crops worldwide. This toxin is known to cause a spectrum of diseases in animals and humans such as vomiting and gastroenteritis. Importantly, DON could inhibit the synthesis of protein and nucleonic acid and induce cell apoptosis in eukaryote cells. The transduction of signaling pathways is involved in the underlying mechanism of the cytotoxicity of DON. Mitogen-activated protein kinase and Janus kinase/signal transducer and activator of transcription seem to be two important signaling pathways and induce the inflammatory response by modulating the binding activates of specific transcription factors. This review mainly discussed the toxic mechanism of DON from the vantage pointof signaling pathways and also assessed the profiles of DON and its metabolites in humans. Importantly, we conducted a human exposure risk assessment of DON from cereals, cereal-based foods, vegetables, water, and animal-derived foods in

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Archives of Toxicology

ISSN

0340-5761

e-ISSN

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Svazek periodika

88

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

14

Strana od-do

1915-1928

Kód UT WoS článku

000344070300003

EID výsledku v databázi Scopus

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