Deoxynivalenol: Emerging Toxic Mechanisms and Control Strategies, Current and Future Perspectives

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F23%3A50020546" target="_blank" >RIV/62690094:18470/23:50020546 - isvavai.cz</a>

Výsledek na webu

<a href="https://pubs.acs.org/doi/10.1021/acs.jafc.3c02020" target="_blank" >https://pubs.acs.org/doi/10.1021/acs.jafc.3c02020</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acs.jafc.3c02020" target="_blank" >10.1021/acs.jafc.3c02020</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Deoxynivalenol: Emerging Toxic Mechanisms and Control Strategies, Current and Future Perspectives

Popis výsledku v původním jazyce

Deoxynivalenol (DON) is the most frequently present mycotoxin contaminant in food and feed, causing a variety of toxic effects in humans and animals. Currently, a series of mechanisms involved in DON toxicity have been identified. In addition to the activation of oxidative stress and the MAPK signaling pathway, DON can activate hypoxia-inducible factor-1 alpha, which further regulates reactive oxygen species production and cancer cell apoptosis. Noncoding RNA and signaling pathways including Wnt/beta-catenin, FOXO, and TLR4/NF-kappa B also participate in DON toxicity. The intestinal microbiota and the brain-gut axis play a crucial role in DON-induced growth inhibition. In view of the synergistic toxic effect of DON and other mycotoxins, strategies to detect DON and control it biologically and the development of enzymes for the biodegradation of various mycotoxins and their introduction in the market are the current and future research hotspots.

Název v anglickém jazyce

Deoxynivalenol: Emerging Toxic Mechanisms and Control Strategies, Current and Future Perspectives

Popis výsledku anglicky

Deoxynivalenol (DON) is the most frequently present mycotoxin contaminant in food and feed, causing a variety of toxic effects in humans and animals. Currently, a series of mechanisms involved in DON toxicity have been identified. In addition to the activation of oxidative stress and the MAPK signaling pathway, DON can activate hypoxia-inducible factor-1 alpha, which further regulates reactive oxygen species production and cancer cell apoptosis. Noncoding RNA and signaling pathways including Wnt/beta-catenin, FOXO, and TLR4/NF-kappa B also participate in DON toxicity. The intestinal microbiota and the brain-gut axis play a crucial role in DON-induced growth inhibition. In view of the synergistic toxic effect of DON and other mycotoxins, strategies to detect DON and control it biologically and the development of enzymes for the biodegradation of various mycotoxins and their introduction in the market are the current and future research hotspots.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30108 - Toxicology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

ISSN

0021-8561

e-ISSN

1520-5118

Svazek periodika

71

Číslo periodika v rámci svazku

29

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

15

Strana od-do

10901-10915

Kód UT WoS článku

001029054000001

EID výsledku v databázi Scopus

2-s2.0-85165619753