Lipoprotein-associated phospholipase A2 mass level is increased in elderly subjects with type 2 diabetes mellitus

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F14%3A10283845" target="_blank" >RIV/00179906:_____/14:10283845 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11150/14:10283845

Výsledek na webu

<a href="http://dx.doi.org/10.1155/2014/278063" target="_blank" >http://dx.doi.org/10.1155/2014/278063</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1155/2014/278063" target="_blank" >10.1155/2014/278063</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Lipoprotein-associated phospholipase A2 mass level is increased in elderly subjects with type 2 diabetes mellitus

Popis výsledku v původním jazyce

Objective. Lipoprotein-associated phospholipase A2 (Lp-PLA 2) is extensively expressed by advanced atherosclerotic lesions and may play a role in plaque instability. We selected a group of elderly subjects that underwent transcatheter aortic valve implantation (TAVI) or balloon angioplasty (BA) and separated them into two groups, diabetic and nondiabetic, to compare the level of Lp-PLA2 mass between them. Methods. 44 patients aged 79.6 +- 5.6 years with symptomatic severe aortic valve stenosis underwentTAVI (n = 35) or BA (n = 9). 21 subjects had confirmed type 2 diabetes mellitus. Lp-PLA2 mass was measured using an enzyme-linked immunosorbent assay kit (USCN Life Science, China) before and 3 days after the procedure. Results. Lp-PLA2 mass was significantly elevated in this population (1296 +- 358 ng/mL before TAVI; 1413 +- 268 ng/mL before BA) and further increased after TAVI (1604 +- 437 ng/mL, P < 0. 01) or BA (1808 +- 303 ng/mL, P < 0. 01). Lp-PLA2 mass was significantly increased

Název v anglickém jazyce

Lipoprotein-associated phospholipase A2 mass level is increased in elderly subjects with type 2 diabetes mellitus

Popis výsledku anglicky

Objective. Lipoprotein-associated phospholipase A2 (Lp-PLA 2) is extensively expressed by advanced atherosclerotic lesions and may play a role in plaque instability. We selected a group of elderly subjects that underwent transcatheter aortic valve implantation (TAVI) or balloon angioplasty (BA) and separated them into two groups, diabetic and nondiabetic, to compare the level of Lp-PLA2 mass between them. Methods. 44 patients aged 79.6 +- 5.6 years with symptomatic severe aortic valve stenosis underwentTAVI (n = 35) or BA (n = 9). 21 subjects had confirmed type 2 diabetes mellitus. Lp-PLA2 mass was measured using an enzyme-linked immunosorbent assay kit (USCN Life Science, China) before and 3 days after the procedure. Results. Lp-PLA2 mass was significantly elevated in this population (1296 +- 358 ng/mL before TAVI; 1413 +- 268 ng/mL before BA) and further increased after TAVI (1604 +- 437 ng/mL, P < 0. 01) or BA (1808 +- 303 ng/mL, P < 0. 01). Lp-PLA2 mass was significantly increased

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

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Projekt

<a href="/cs/project/NT12287" target="_blank" >NT12287: Význam insulinové resistence v patogenezi kardiometabolického rizika u diabetes mellitus</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Diabetes Research

ISSN

2314-6745

e-ISSN

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Svazek periodika

2014

Číslo periodika v rámci svazku

10 April

Stát vydavatele periodika

EG - Egyptská arabská republika

Počet stran výsledku

6

Strana od-do

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Kód UT WoS článku

000334777800001

EID výsledku v databázi Scopus

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