Diagnostic performance of urinary metanephrines for the postmortem diagnosis of hypothermia

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F14%3A10284349" target="_blank" >RIV/00179906:_____/14:10284349 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11150/14:10284349

Výsledek na webu

<a href="http://dx.doi.org/10.1007/s12024-014-9585-0" target="_blank" >http://dx.doi.org/10.1007/s12024-014-9585-0</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s12024-014-9585-0" target="_blank" >10.1007/s12024-014-9585-0</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Diagnostic performance of urinary metanephrines for the postmortem diagnosis of hypothermia

Popis výsledku v původním jazyce

The purpose of this study was to assess the diagnostic potential of urinary metanephrines and 3-methoxytyramine compared to urinary catecholamine determination in diagnosing antemortem cold exposure and fatal hypothermia. 83 cases of fatal hypothermia and 144 control cases were included in this study. Catecholamines (adrenaline, noradrenaline and dopamine), metanephrines (metanephrine, normetanephrine) and 3-methoxytyramine were measured in urine collected during autopsy. All tested analytes were significantly higher in hypothermia cases compared to control subjects and displayed a generally satisfying discriminative value, thus indicating urinary catecholamines and their metabolites as reliable markers of cold-related stress and hypothermia related-deaths. Metanephrine and adrenaline had the best discriminative value between hypothermia and control cases compared to other tested analytes, though with different sensitivity and specificity. These can therefore be considered the most sui

Název v anglickém jazyce

Diagnostic performance of urinary metanephrines for the postmortem diagnosis of hypothermia

Popis výsledku anglicky

The purpose of this study was to assess the diagnostic potential of urinary metanephrines and 3-methoxytyramine compared to urinary catecholamine determination in diagnosing antemortem cold exposure and fatal hypothermia. 83 cases of fatal hypothermia and 144 control cases were included in this study. Catecholamines (adrenaline, noradrenaline and dopamine), metanephrines (metanephrine, normetanephrine) and 3-methoxytyramine were measured in urine collected during autopsy. All tested analytes were significantly higher in hypothermia cases compared to control subjects and displayed a generally satisfying discriminative value, thus indicating urinary catecholamines and their metabolites as reliable markers of cold-related stress and hypothermia related-deaths. Metanephrine and adrenaline had the best discriminative value between hypothermia and control cases compared to other tested analytes, though with different sensitivity and specificity. These can therefore be considered the most sui

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EA - Morfologické obory a cytologie

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Forensic Science, Medicine, and Pathology

ISSN

1547-769X

e-ISSN

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Svazek periodika

10

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

518-525

Kód UT WoS článku

000344874800007

EID výsledku v databázi Scopus

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