Preparation of pellets with controlled release of glucose as prevention of hypoglycaemia in paediatric patients

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F15%3A10301824" target="_blank" >RIV/00179906:_____/15:10301824 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/62157124:16370/15:43873517

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.ejps.2015.03.007" target="_blank" >http://dx.doi.org/10.1016/j.ejps.2015.03.007</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ejps.2015.03.007" target="_blank" >10.1016/j.ejps.2015.03.007</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Preparation of pellets with controlled release of glucose as prevention of hypoglycaemia in paediatric patients

Popis výsledku v původním jazyce

Hypoglycaemic episodes represent serious and frequent complications of type 1 and 2 diabetes. Theoretically, the risk of hypoglycaemic states can be affected by a dosage form based on a food supplement containing a delayed release formulation of glucose. The release of glucose should compensate for balance the peak effect of an antidiabetic treatment. In clinical practice, a diet with fibre and grains is recommended and patients are broadly educated in the topic of low and high glycaemic indexes to achieve the same effect. However, a precisely-timed release of carbohydrates can favourably target expected hypoglycaemia and concurrently decrease carbohydrate content. To study the possibility of preparing the dosage form with controlled-release carbohydrates, a dosage form of pellets containing four osmotically active substances coated by a membrane created of ethylcellulose was prepared. These pellets can be administered in a mixture with liquid or semisolid food. The resulting dissolution profiles for selected compositions showed that delayed release can be achieved for 120, 240 and 360 min in vitro, representing an ideal delay for clinical purposes.

Název v anglickém jazyce

Preparation of pellets with controlled release of glucose as prevention of hypoglycaemia in paediatric patients

Popis výsledku anglicky

Hypoglycaemic episodes represent serious and frequent complications of type 1 and 2 diabetes. Theoretically, the risk of hypoglycaemic states can be affected by a dosage form based on a food supplement containing a delayed release formulation of glucose. The release of glucose should compensate for balance the peak effect of an antidiabetic treatment. In clinical practice, a diet with fibre and grains is recommended and patients are broadly educated in the topic of low and high glycaemic indexes to achieve the same effect. However, a precisely-timed release of carbohydrates can favourably target expected hypoglycaemia and concurrently decrease carbohydrate content. To study the possibility of preparing the dosage form with controlled-release carbohydrates, a dosage form of pellets containing four osmotically active substances coated by a membrane created of ethylcellulose was prepared. These pellets can be administered in a mixture with liquid or semisolid food. The resulting dissolution profiles for selected compositions showed that delayed release can be achieved for 120, 240 and 360 min in vitro, representing an ideal delay for clinical purposes.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FG - Pediatrie

OECD FORD obor

—

Projekt

<a href="/cs/project/NT14479" target="_blank" >NT14479: Příprava lékové formy s řízeným uvolňováním glukosy k prevenci hypoglykemických stavů.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Journal of Pharmaceutical Sciences

ISSN

0928-0987

e-ISSN

—

Svazek periodika

75

Číslo periodika v rámci svazku

SI

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

9

Strana od-do

72-80

Kód UT WoS článku

000356552500008

EID výsledku v databázi Scopus

2-s2.0-84929963978