Coated pellets with delayed-release glucose for prevention of hypoglycemic episodes

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F16%3A10332545" target="_blank" >RIV/00179906:_____/16:10332545 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/62157124:16370/16:43874281

Výsledek na webu

<a href="http://dx.doi.org/10.1515/acph-2016-0017" target="_blank" >http://dx.doi.org/10.1515/acph-2016-0017</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1515/acph-2016-0017" target="_blank" >10.1515/acph-2016-0017</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Coated pellets with delayed-release glucose for prevention of hypoglycemic episodes

Popis výsledku v původním jazyce

Patients tend to prevent hypoglycemia by excessive saccharide intake leading to poorer glycemic control with potentially fatal consequences. This problem could be resolved by means of pellets with glucose release delayed by 120-360 min as a compensation of the antidiabetic drug peak effect. No glucose is released before; hence there is no risk of hyperglycemia and secondary complications. The pellets contain glucose in combination with an osmotically active ingredient and are coated with an ethylcellulose dispersion, which forms an insoluble semipermeable membrane and ensures delayed release. The release of glucose was assessed using dissolution and high-performance liquid chromatography. Dissolution profiles indicated the possibility of achieving the requested lag time using a combination of adequate compositions and coating concentrations. Lag times of 60, 240 and 360 min were achieved. The sample containing carboxymethyl starch was found to be most suitable for the intent of this work.

Název v anglickém jazyce

Coated pellets with delayed-release glucose for prevention of hypoglycemic episodes

Popis výsledku anglicky

Patients tend to prevent hypoglycemia by excessive saccharide intake leading to poorer glycemic control with potentially fatal consequences. This problem could be resolved by means of pellets with glucose release delayed by 120-360 min as a compensation of the antidiabetic drug peak effect. No glucose is released before; hence there is no risk of hyperglycemia and secondary complications. The pellets contain glucose in combination with an osmotically active ingredient and are coated with an ethylcellulose dispersion, which forms an insoluble semipermeable membrane and ensures delayed release. The release of glucose was assessed using dissolution and high-performance liquid chromatography. Dissolution profiles indicated the possibility of achieving the requested lag time using a combination of adequate compositions and coating concentrations. Lag times of 60, 240 and 360 min were achieved. The sample containing carboxymethyl starch was found to be most suitable for the intent of this work.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

—

Projekt

<a href="/cs/project/NT14479" target="_blank" >NT14479: Příprava lékové formy s řízeným uvolňováním glukosy k prevenci hypoglykemických stavů.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Acta Pharmaceutica

ISSN

1330-0075

e-ISSN

—

Svazek periodika

66

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

HR - Chorvatská republika

Počet stran výsledku

11

Strana od-do

257-267

Kód UT WoS článku

000377425200008

EID výsledku v databázi Scopus

2-s2.0-84974676860