Severe deoxyribonucleic acid damage after out-of-hospital cardiac arrest in successfully resuscitated humans

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F16%3A10323422" target="_blank" >RIV/00179906:_____/16:10323422 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11150/16:10323422

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.ijcard.2016.01.046" target="_blank" >http://dx.doi.org/10.1016/j.ijcard.2016.01.046</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ijcard.2016.01.046" target="_blank" >10.1016/j.ijcard.2016.01.046</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Severe deoxyribonucleic acid damage after out-of-hospital cardiac arrest in successfully resuscitated humans

Popis výsledku v původním jazyce

Out-of-hospital cardiac arrest (OHCA) is a highly stressful event with a transient common ischaemic - reperfusion injury in successfully resuscitated victims. Survival rate of patients resuscitated from OHCA remains too low (10%) [1]. It has been shown that stress induces the most severe form of deoxyribonucleic acid (DNA) damage - double strand breaks (DSBs) [2], [3], [4] and [5]. The reliable marker of DNA DSB damage, respectively its reparation is the phosphorylated histone H2AX (γH2AX), which reaches maximum levels in peripheral blood lymphocytes between 10 and 60 min following cell exposure [3], [4], [5], [6], [7] and [8]. The effect of OHCA on DNA integrity has not been described. Thus the aim of the authors was to describe in patients successfully resuscitated from OHCA the occurrence of DNA DSB damage and evaluate γH2AX short-term prognostic (30-day survival) role.

Název v anglickém jazyce

Severe deoxyribonucleic acid damage after out-of-hospital cardiac arrest in successfully resuscitated humans

Popis výsledku anglicky

Out-of-hospital cardiac arrest (OHCA) is a highly stressful event with a transient common ischaemic - reperfusion injury in successfully resuscitated victims. Survival rate of patients resuscitated from OHCA remains too low (10%) [1]. It has been shown that stress induces the most severe form of deoxyribonucleic acid (DNA) damage - double strand breaks (DSBs) [2], [3], [4] and [5]. The reliable marker of DNA DSB damage, respectively its reparation is the phosphorylated histone H2AX (γH2AX), which reaches maximum levels in peripheral blood lymphocytes between 10 and 60 min following cell exposure [3], [4], [5], [6], [7] and [8]. The effect of OHCA on DNA integrity has not been described. Thus the aim of the authors was to describe in patients successfully resuscitated from OHCA the occurrence of DNA DSB damage and evaluate γH2AX short-term prognostic (30-day survival) role.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

—

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Cardiology

ISSN

0167-5273

e-ISSN

—

Svazek periodika

207

Číslo periodika v rámci svazku

March

Stát vydavatele periodika

IE - Irsko

Počet stran výsledku

3

Strana od-do

33-35

Kód UT WoS článku

000371271400010

EID výsledku v databázi Scopus

2-s2.0-84957936142