Laboratory-Based Markers as Predictors of Brain Infarction During Carotid Stenting: a Prospective Study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F16%3A10328053" target="_blank" >RIV/00179906:_____/16:10328053 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/16:10328053 RIV/00216208:11150/16:10328053 RIV/61989592:15120/16:33159205 RIV/00843989:_____/16:E0105487 RIV/61988987:17110/16:A210288V

Výsledek na webu

<a href="https://www.jstage.jst.go.jp/article/jat/advpub/0/advpub_31799/_pdf" target="_blank" >https://www.jstage.jst.go.jp/article/jat/advpub/0/advpub_31799/_pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5551/jat.31799" target="_blank" >10.5551/jat.31799</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Laboratory-Based Markers as Predictors of Brain Infarction During Carotid Stenting: a Prospective Study

Popis výsledku v původním jazyce

Aim: New ischemic lesions in the brain can be detected in approximately 50% of patients undergoing carotid artery stenting (CAS). We wished to discover the laboratory-based predictors of new infarctions in the brain after CAS. Methods: All consecutive patients with internal carotid artery stenosis of >= 70% with indication for CAS were enrolled in a prospective study for 16 months. All patients used dual antiplatelet therapy for >= 7 days before CAS. Neurologic examination and magnetic resonance imaging (MRI) of the brain were undertaken before and at 24 h after CAS. Samples of venous blood were collected at <24 h before CAS for the evaluation of hematology, reticulocytes, coagulation markers (PT, APTT, Fbg, Clauss), vWF antigen, PAI-1 activity, PAI-1 polymorphism 4G/5G, and the multiplate (aspirin and clopidogrel) resistance test. Blood samples for the assessment of anti-Xa activity were collected during CAS. Differences in the values of laboratory markers between patients with and without new ischemic lesions of the brain on control MRI were evaluated. Results: The cohort comprised 81 patients (53 males; mean age, 67.3 +/- 7.2 years). New ischemic infarctions in the brain on control MRI were found in 46 (56.8%) patients. Three of seven patients with resistance to aspirin or clopidogrel had a new ischemic infarction in the brain. No significant differences for particular markers were found between patients with and without an ischemic lesion in the brain. Conclusion: A high risk of a new ischemic infarction in the brain was detected in patients undergoing CAS, but a laboratory-based predictor of such an infarction could not be identified.

Název v anglickém jazyce

Laboratory-Based Markers as Predictors of Brain Infarction During Carotid Stenting: a Prospective Study

Popis výsledku anglicky

Aim: New ischemic lesions in the brain can be detected in approximately 50% of patients undergoing carotid artery stenting (CAS). We wished to discover the laboratory-based predictors of new infarctions in the brain after CAS. Methods: All consecutive patients with internal carotid artery stenosis of >= 70% with indication for CAS were enrolled in a prospective study for 16 months. All patients used dual antiplatelet therapy for >= 7 days before CAS. Neurologic examination and magnetic resonance imaging (MRI) of the brain were undertaken before and at 24 h after CAS. Samples of venous blood were collected at <24 h before CAS for the evaluation of hematology, reticulocytes, coagulation markers (PT, APTT, Fbg, Clauss), vWF antigen, PAI-1 activity, PAI-1 polymorphism 4G/5G, and the multiplate (aspirin and clopidogrel) resistance test. Blood samples for the assessment of anti-Xa activity were collected during CAS. Differences in the values of laboratory markers between patients with and without new ischemic lesions of the brain on control MRI were evaluated. Results: The cohort comprised 81 patients (53 males; mean age, 67.3 +/- 7.2 years). New ischemic infarctions in the brain on control MRI were found in 46 (56.8%) patients. Three of seven patients with resistance to aspirin or clopidogrel had a new ischemic infarction in the brain. No significant differences for particular markers were found between patients with and without an ischemic lesion in the brain. Conclusion: A high risk of a new ischemic infarction in the brain was detected in patients undergoing CAS, but a laboratory-based predictor of such an infarction could not be identified.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

—

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of atherosclerosis and thrombosis

ISSN

1340-3478

e-ISSN

—

Svazek periodika

23

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

JP - Japonsko

Počet stran výsledku

9

Strana od-do

839-847

Kód UT WoS článku

000384912100011

EID výsledku v databázi Scopus

2-s2.0-84976643792