Influence of the chronic groundwater fluoride consumption on cholinergic enzymes, ACHE and BCHE gene SNPs and pro-inflammatory cytokines: A study with Pakistani population groups
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F23%3A10464993" target="_blank" >RIV/00179906:_____/23:10464993 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/62690094:18470/23:50020383
Výsledek na webu
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=1qEVx5fUxB" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=1qEVx5fUxB</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.scitotenv.2023.163359" target="_blank" >10.1016/j.scitotenv.2023.163359</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Influence of the chronic groundwater fluoride consumption on cholinergic enzymes, ACHE and BCHE gene SNPs and pro-inflammatory cytokines: A study with Pakistani population groups
Popis výsledku v původním jazyce
Fluoride is one of the abundant elements found in the Earth's crust and is a global environmental issue. The present work aimed to find the impact of chronic consumption of fluoride contained groundwater on human subjects. Five hundred and twelve volunteers from different areas of Pakistan were recruited. Cholinergic status, acetylcholinesterase and butyrylcho-linesterase gene SNPs and pro-inflammatory cytokines were examined. Association analysis, regression and other stan-dard statistical analyses were performed. Physical examination of the fluoride endemic areas' participants revealed the symptoms of dental and skeletal fluorosis. Cholinergic enzymes (AChE and BChE) were significantly increased among dif-ferent exposure groups. ACHE gene 3 '-UTR variant and BCHE K-variant showed a significant association with risk of fluo-rosis. Pro-inflammatory cytokines (TNF-alpha, IL-1 beta and IL-6) were found to be increased and have a significant correlation in response to fluoride exposure and cholinergic enzymes. The study concludes that chronic consumption of high fluoride -contained water is a risk factor for developing low-grade systemic inflammation through the cholinergic pathway and the studied cholinergic gene SNPs were identified to be associated with the risk of flurosis.
Název v anglickém jazyce
Influence of the chronic groundwater fluoride consumption on cholinergic enzymes, ACHE and BCHE gene SNPs and pro-inflammatory cytokines: A study with Pakistani population groups
Popis výsledku anglicky
Fluoride is one of the abundant elements found in the Earth's crust and is a global environmental issue. The present work aimed to find the impact of chronic consumption of fluoride contained groundwater on human subjects. Five hundred and twelve volunteers from different areas of Pakistan were recruited. Cholinergic status, acetylcholinesterase and butyrylcho-linesterase gene SNPs and pro-inflammatory cytokines were examined. Association analysis, regression and other stan-dard statistical analyses were performed. Physical examination of the fluoride endemic areas' participants revealed the symptoms of dental and skeletal fluorosis. Cholinergic enzymes (AChE and BChE) were significantly increased among dif-ferent exposure groups. ACHE gene 3 '-UTR variant and BCHE K-variant showed a significant association with risk of fluo-rosis. Pro-inflammatory cytokines (TNF-alpha, IL-1 beta and IL-6) were found to be increased and have a significant correlation in response to fluoride exposure and cholinergic enzymes. The study concludes that chronic consumption of high fluoride -contained water is a risk factor for developing low-grade systemic inflammation through the cholinergic pathway and the studied cholinergic gene SNPs were identified to be associated with the risk of flurosis.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
30104 - Pharmacology and pharmacy
Návaznosti výsledku
Projekt
—
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2023
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Science of the Total Environment
ISSN
0048-9697
e-ISSN
1879-1026
Svazek periodika
880
Číslo periodika v rámci svazku
Jul
Stát vydavatele periodika
NL - Nizozemsko
Počet stran výsledku
10
Strana od-do
163359
Kód UT WoS článku
000981838400001
EID výsledku v databázi Scopus
2-s2.0-85152378481