Retinal microvascular abnormalities in major depression

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F24%3A10481544" target="_blank" >RIV/00179906:_____/24:10481544 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11150/24:10481544

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=og64LiX_ws" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=og64LiX_ws</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5507/bp.2023.026" target="_blank" >10.5507/bp.2023.026</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Retinal microvascular abnormalities in major depression

Popis výsledku v původním jazyce

Background: The aim of our study was to find a possible association between retinal microvascular abnormality and major depression in a non-geriatric population.Method: The participants with major depression were hospitalised at the University Hospital in Hradec Kralove, Department of Psychiatry. Retinal images were obtained using a stationary Fundus camera FF450 by Zeiss and a hand-held camera by oDocs.Results: Fifty patients (men n=18, women n=32) aged 16 to 55 (men&apos;s average age 33.7+-9.9 years, women&apos;s average age 37.9+-11.5 years) were compared with fifty mentally healthy subjects (men n=28, women n=22) aged 18 to 61 (men&apos;s average age 35.3+-9.2 years, women&apos;s average age 36.6+-10.6 years) in a cross-sectional design. The patients were diagnosed with a single depressive episode (n=26) or a recurrent depressive disorder (n=24) according to the ICD-10 classification. Our results confirmed significant microvascular changes in the retina in patients with depressive disorder in comparison to the control group of mentally healthy subjects, with significantly larger arteriolar (P&lt;0.0001) as well as venular (P&lt;0.001-0.0001) calibres in major depression.Conclusion: According to the literature, acute and chronic neuroinflammation is associated with changes in microvascular form and function. The endothelium becomes a major participant in the inflammatory response damaging the surrounding tissue and its function. Because the retina and brain tissue share a common embryonic origin, we suspect similar microvascular pathology in the retina and in the brain in major depression. Our results may contribute to a better understanding of depression etiopathogenesis and to its personalized treatment.

Název v anglickém jazyce

Retinal microvascular abnormalities in major depression

Popis výsledku anglicky

Background: The aim of our study was to find a possible association between retinal microvascular abnormality and major depression in a non-geriatric population.Method: The participants with major depression were hospitalised at the University Hospital in Hradec Kralove, Department of Psychiatry. Retinal images were obtained using a stationary Fundus camera FF450 by Zeiss and a hand-held camera by oDocs.Results: Fifty patients (men n=18, women n=32) aged 16 to 55 (men&apos;s average age 33.7+-9.9 years, women&apos;s average age 37.9+-11.5 years) were compared with fifty mentally healthy subjects (men n=28, women n=22) aged 18 to 61 (men&apos;s average age 35.3+-9.2 years, women&apos;s average age 36.6+-10.6 years) in a cross-sectional design. The patients were diagnosed with a single depressive episode (n=26) or a recurrent depressive disorder (n=24) according to the ICD-10 classification. Our results confirmed significant microvascular changes in the retina in patients with depressive disorder in comparison to the control group of mentally healthy subjects, with significantly larger arteriolar (P&lt;0.0001) as well as venular (P&lt;0.001-0.0001) calibres in major depression.Conclusion: According to the literature, acute and chronic neuroinflammation is associated with changes in microvascular form and function. The endothelium becomes a major participant in the inflammatory response damaging the surrounding tissue and its function. Because the retina and brain tissue share a common embryonic origin, we suspect similar microvascular pathology in the retina and in the brain in major depression. Our results may contribute to a better understanding of depression etiopathogenesis and to its personalized treatment.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30215 - Psychiatry

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biomedical Papers

ISSN

1213-8118

e-ISSN

1804-7521

Svazek periodika

168

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

9

Strana od-do

147-155

Kód UT WoS článku

001033673800001

EID výsledku v databázi Scopus

2-s2.0-85196327166