Widened retinal arteriolar and venular diameters are not an endophenotype of schizophrenia: A one-time cross-sectional study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F23%3A00581878" target="_blank" >RIV/67985904:_____/23:00581878 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14310/23:00133104 RIV/61988987:17110/23:A2402M7Q RIV/00216208:11150/23:10468843 RIV/00179906:_____/23:10468843 a 2 dalších

Výsledek na webu

<a href="https://www.researchgate.net/publication/372807895_Widened_retinal_arteriolar_and_venular_diameters_are_not_an_endophenotype_of_schizophrenia_A_one-time_cross-sectional_study" target="_blank" >https://www.researchgate.net/publication/372807895_Widened_retinal_arteriolar_and_venular_diameters_are_not_an_endophenotype_of_schizophrenia_A_one-time_cross-sectional_study</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Widened retinal arteriolar and venular diameters are not an endophenotype of schizophrenia: A one-time cross-sectional study

Popis výsledku v původním jazyce

OBJECTIVES: Studies of schizophrenia endophenotypes may help clinicians better understand the etiopathogenesis and treatment of this mental disorder. The aim of the study was to determine if retinal arteriolar or venular abnormalities are an endophenotype of schizophrenia.nDESIGN: We performed a one-time cross-sectional study.nMATERIALS AND METHODS: We enlisted schizophrenic patients (n = 53) hospitalized in the Department of Psychiatry, University Hospital Hradec Kralove, their mentally healthy first-degree relatives (n = 53) and unrelated, age- and sex-matched mentally healthy controls (n = 49). We recorded all participants ' sociodemographic and, if relevant, clinical variables. Retinal imaging was carried out using a digital fundus camera (FF450 + IR). Outcomes included retinal vessel calibers measured using the software application VAMPIRE.nRESULTS: The study enrolled fifty-three schizophrenic patients (average age 32.1 years, males n = 38), an equal number of healthy relatives (average age 47.3 years, males n = 18), and forty-nine unrelated healthy controls (average age 32.2 years, males n = 35). Patients with schizophrenia had significantly increased retinal arteriolar diameters when compared to unrelated healthy controls (left eye p = 0.003, right eye p = 0.011) but not when compared to healthy relatives. The sizes of the retinal venules were not significantly different among the study groups.nCONCLUSIONS: Our cross-sectional findings do not support the notion that retinal microvascular anomalies are an endophenotype in schizophrenia. Longitudinal studies of this subject should be included in further research.

Název v anglickém jazyce

Widened retinal arteriolar and venular diameters are not an endophenotype of schizophrenia: A one-time cross-sectional study

Popis výsledku anglicky

OBJECTIVES: Studies of schizophrenia endophenotypes may help clinicians better understand the etiopathogenesis and treatment of this mental disorder. The aim of the study was to determine if retinal arteriolar or venular abnormalities are an endophenotype of schizophrenia.nDESIGN: We performed a one-time cross-sectional study.nMATERIALS AND METHODS: We enlisted schizophrenic patients (n = 53) hospitalized in the Department of Psychiatry, University Hospital Hradec Kralove, their mentally healthy first-degree relatives (n = 53) and unrelated, age- and sex-matched mentally healthy controls (n = 49). We recorded all participants ' sociodemographic and, if relevant, clinical variables. Retinal imaging was carried out using a digital fundus camera (FF450 + IR). Outcomes included retinal vessel calibers measured using the software application VAMPIRE.nRESULTS: The study enrolled fifty-three schizophrenic patients (average age 32.1 years, males n = 38), an equal number of healthy relatives (average age 47.3 years, males n = 18), and forty-nine unrelated healthy controls (average age 32.2 years, males n = 35). Patients with schizophrenia had significantly increased retinal arteriolar diameters when compared to unrelated healthy controls (left eye p = 0.003, right eye p = 0.011) but not when compared to healthy relatives. The sizes of the retinal venules were not significantly different among the study groups.nCONCLUSIONS: Our cross-sectional findings do not support the notion that retinal microvascular anomalies are an endophenotype in schizophrenia. Longitudinal studies of this subject should be included in further research.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

30215 - Psychiatry

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Neuroendocrinology Letters

ISSN

0172-780X

e-ISSN

2354-4716

Svazek periodika

44

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

SE - Švédské království

Počet stran výsledku

296

Strana od-do

290-296

Kód UT WoS článku

001101642500003

EID výsledku v databázi Scopus

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