Role of Intrauterine Infectious and Inflammatory Complications in the Development of Necrotizing Enterocolitis in a Newborn from Preterm Prelabor Rupture of Membranes' Gestation: A Retrospective Cohort Study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F25%3A10499774" target="_blank" >RIV/00179906:_____/25:10499774 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11150/25:10499774

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=JsKJr-cktc" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=JsKJr-cktc</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1159/000546257" target="_blank" >10.1159/000546257</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Role of Intrauterine Infectious and Inflammatory Complications in the Development of Necrotizing Enterocolitis in a Newborn from Preterm Prelabor Rupture of Membranes' Gestation: A Retrospective Cohort Study

Popis výsledku v původním jazyce

Introduction: This study aimed to evaluate whether the presence of microbial invasion of the amniotic cavity (MIAC) and/or acute histological chorioamnionitis (HCA), as well as their subtypes, in pregnancies complicated by preterm prelabor rupture of membranes (PPROM) is related to the subsequent development of necrotizing enterocolitis (NEC) in newborns from these pregnancies. Methods: This retrospective study included 295 women with singleton pregnancies complicated by PPROM between gestational ages 24+0 and 31+6 weeks who underwent transabdominal amniocentesis. MIAC was detected using a combination of cultivated and noncultivated methods. HCA was revealed by histopathological examination of the placenta. Only neonates with stage IIa of the modified Bell&apos;s criteria were considered to have NEC. Results: NEC developed in 3% (10/295) of newborns. There were no differences in the rates of MIAC (p = 0.33), HCA with the absence (p = 1.00) or presence of fetal inflammatory response (p = 0.52), and HCA with acute inflammation of the amnion (p = 0.20) between those who developed and did not develop NEC. Conclusion: Neither MIAC nor HCA was associated with the development of NEC in newborns from singleton pregnancies complicated by PPROM between 24+0 and 31+6 weeks of gestation.

Název v anglickém jazyce

Role of Intrauterine Infectious and Inflammatory Complications in the Development of Necrotizing Enterocolitis in a Newborn from Preterm Prelabor Rupture of Membranes' Gestation: A Retrospective Cohort Study

Popis výsledku anglicky

Introduction: This study aimed to evaluate whether the presence of microbial invasion of the amniotic cavity (MIAC) and/or acute histological chorioamnionitis (HCA), as well as their subtypes, in pregnancies complicated by preterm prelabor rupture of membranes (PPROM) is related to the subsequent development of necrotizing enterocolitis (NEC) in newborns from these pregnancies. Methods: This retrospective study included 295 women with singleton pregnancies complicated by PPROM between gestational ages 24+0 and 31+6 weeks who underwent transabdominal amniocentesis. MIAC was detected using a combination of cultivated and noncultivated methods. HCA was revealed by histopathological examination of the placenta. Only neonates with stage IIa of the modified Bell&apos;s criteria were considered to have NEC. Results: NEC developed in 3% (10/295) of newborns. There were no differences in the rates of MIAC (p = 0.33), HCA with the absence (p = 1.00) or presence of fetal inflammatory response (p = 0.52), and HCA with acute inflammation of the amnion (p = 0.20) between those who developed and did not develop NEC. Conclusion: Neither MIAC nor HCA was associated with the development of NEC in newborns from singleton pregnancies complicated by PPROM between 24+0 and 31+6 weeks of gestation.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30200 - Clinical medicine

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Fetal Diagnosis and Therapy

ISSN

1015-3837

e-ISSN

1421-9964

Svazek periodika

52

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

15

Strana od-do

468-482

Kód UT WoS článku

001516929500001

EID výsledku v databázi Scopus

2-s2.0-105009713946