Current Insights of the Potential Plant Bioactive Compounds on Modulating the mTOR Signaling Pathway in Regulating Oncological Disorders

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F25%3A10500503" target="_blank" >RIV/00179906:_____/25:10500503 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/62690094:18470/25:50022503 RIV/62690094:18450/25:50022503 RIV/61989100:27360/25:10260332

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=CTaW~K.1V2" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=CTaW~K.1V2</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/ptr.70051" target="_blank" >10.1002/ptr.70051</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Current Insights of the Potential Plant Bioactive Compounds on Modulating the mTOR Signaling Pathway in Regulating Oncological Disorders

Popis výsledku v původním jazyce

Deregulation of the mechanistic target of the rapamycin (mTOR) pathway plays an important role in cancer genesis and progression, making it an attractive target for cancer treatment. Disrupting the mTOR pathway contributes to uncontrolled cell growth, increased proliferation, and enhanced cell survival, all of which are hallmarks of cancer. The findings imply that the deregulation of the mTOR pathway in cancer provides a compelling basis for therapeutic treatments. Phytochemicals such as flavonoids and polyphenols have been shown to play a key role in suppressing different kinases implicated in PI3K/AKT/mTOR signaling cascades. A thorough study of the molecular connections between bioactive substances, mTOR signaling, and autophagy activation can lead to the creation of personalized treatments that work better and have fewer side effects. Finding out how important it is to target the mTOR pathway and how to use bioactive chemicals from plants to treat cancer are both important discoveries that could lead to more precise medicine and the development of effective cancer drugs. Finally, targeting mTOR pathways using plant-derived chemicals may be a promising therapy strategy for cancer. This review tries to summarize putative plant bioactive chemicals that act on malignancies via mTOR signaling pathways. Furthermore, the paper discusses the role of the mTOR pathway in cancer, specifically its influence on cell growth, proliferation, and survival.

Název v anglickém jazyce

Current Insights of the Potential Plant Bioactive Compounds on Modulating the mTOR Signaling Pathway in Regulating Oncological Disorders

Popis výsledku anglicky

Deregulation of the mechanistic target of the rapamycin (mTOR) pathway plays an important role in cancer genesis and progression, making it an attractive target for cancer treatment. Disrupting the mTOR pathway contributes to uncontrolled cell growth, increased proliferation, and enhanced cell survival, all of which are hallmarks of cancer. The findings imply that the deregulation of the mTOR pathway in cancer provides a compelling basis for therapeutic treatments. Phytochemicals such as flavonoids and polyphenols have been shown to play a key role in suppressing different kinases implicated in PI3K/AKT/mTOR signaling cascades. A thorough study of the molecular connections between bioactive substances, mTOR signaling, and autophagy activation can lead to the creation of personalized treatments that work better and have fewer side effects. Finding out how important it is to target the mTOR pathway and how to use bioactive chemicals from plants to treat cancer are both important discoveries that could lead to more precise medicine and the development of effective cancer drugs. Finally, targeting mTOR pathways using plant-derived chemicals may be a promising therapy strategy for cancer. This review tries to summarize putative plant bioactive chemicals that act on malignancies via mTOR signaling pathways. Furthermore, the paper discusses the role of the mTOR pathway in cancer, specifically its influence on cell growth, proliferation, and survival.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Phytotherapy Research

ISSN

0951-418X

e-ISSN

1099-1573

Svazek periodika

39

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

14

Strana od-do

4046-4059

Kód UT WoS článku

001536907600001

EID výsledku v databázi Scopus

2-s2.0-105011740210