Src-dependent activation of the mTOR signaling in melanoma cells

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A10192022" target="_blank" >RIV/00216208:11110/12:10192022 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Src-dependent activation of the mTOR signaling in melanoma cells

Popis výsledku v původním jazyce

The mammalian target of rapamycin (mTOR) is an important signaling protein that integrates external and internal signals to regulate essential cell functions in a variety of organisms. Deregulation of the mTOR-dependent pathway occurs in many human diseases and may be a selective target for their therapy. However, clinical results obtained by targeting this pathway with mTOR-specific inhibitor rapamycin have shown its limited therapeutic effects. We have found that mTOR signaling is highly upregulated in melanoma cells. This hyperactivity could be reduced by treatment of the cells with rapamycin and by suppression of the activity of tyrosine kinase c-Src, which is comparable with the effect of rapamycin. Inhibition by the Src inhibitor does not lead tophosphorylation of Akt that can be induced by rapamycin, probably by a feedback machanism.

Název v anglickém jazyce

Src-dependent activation of the mTOR signaling in melanoma cells

Popis výsledku anglicky

The mammalian target of rapamycin (mTOR) is an important signaling protein that integrates external and internal signals to regulate essential cell functions in a variety of organisms. Deregulation of the mTOR-dependent pathway occurs in many human diseases and may be a selective target for their therapy. However, clinical results obtained by targeting this pathway with mTOR-specific inhibitor rapamycin have shown its limited therapeutic effects. We have found that mTOR signaling is highly upregulated in melanoma cells. This hyperactivity could be reduced by treatment of the cells with rapamycin and by suppression of the activity of tyrosine kinase c-Src, which is comparable with the effect of rapamycin. Inhibition by the Src inhibitor does not lead tophosphorylation of Akt that can be induced by rapamycin, probably by a feedback machanism.

Druh

D - Stať ve sborníku

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

<a href="/cs/project/NT11231" target="_blank" >NT11231: Ovlivnění signálních drah mTOR a MAPK inhibicí kinázové aktivity Src - význam pro individualizovanou protinádorovou terapii</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

The melanocyte and its environment

ISBN

978-88-7587-678-4

ISSN

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e-ISSN

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Počet stran výsledku

3

Strana od-do

29-31

Název nakladatele

Medimond

Místo vydání

Bologna, Italy

Místo konání akce

Geneva

Datum konání akce

11. 9. 2011

Typ akce podle státní příslušnosti

EUR - Evropská akce

Kód UT WoS článku

000325106100006