Environmental Factors in the Etiology of Mental Disorders in the Czech Republic: Final Results

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F25%3A10502013" target="_blank" >RIV/00179906:_____/25:10502013 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11150/25:10502013

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=Jya82ir84C" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=Jya82ir84C</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2147/NDT.S498992" target="_blank" >10.2147/NDT.S498992</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Environmental Factors in the Etiology of Mental Disorders in the Czech Republic: Final Results

Popis výsledku v původním jazyce

Both genetic and environmental factors are important in etiology of mental disorders. Calculating polyenviromic risk/ protective scores provides an updated perspective in research on the environmental causes of psychiatric disorders. We aimed to compare environmental risk and protective factors in patients with psychosis or a mood disorder (PSYCH+MOOD) and those with an anxiety disorder (ANX). We administered the internationally accepted questionnaire from the EUropean Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI) study, enriched with mood and anxiety disorder-relevant measures, to patients at two large university hospitals in the Czech Republic. Two hundred PSYCH+MOOD patients (average age 42.5 years; 46 males) and two hundred ANX patients (average age 47.2 years; 17 males) participated. Neither polyenviromic risk score nor polyenviromic protective score differed significantly between PSYCH +MOOD and ANX groups (p = 0.149; p = 0.466, respectively). Scientific validity of the polyenviromic risk/protective score construct must still be demonstrated in large psychiatric samples, ideally in prospective studies. Nevertheless, researchers have already started to investigate environmental factors in the etiology of mental disorders in their complexity, similarly to polygenic risk scores.

Název v anglickém jazyce

Environmental Factors in the Etiology of Mental Disorders in the Czech Republic: Final Results

Popis výsledku anglicky

Both genetic and environmental factors are important in etiology of mental disorders. Calculating polyenviromic risk/ protective scores provides an updated perspective in research on the environmental causes of psychiatric disorders. We aimed to compare environmental risk and protective factors in patients with psychosis or a mood disorder (PSYCH+MOOD) and those with an anxiety disorder (ANX). We administered the internationally accepted questionnaire from the EUropean Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI) study, enriched with mood and anxiety disorder-relevant measures, to patients at two large university hospitals in the Czech Republic. Two hundred PSYCH+MOOD patients (average age 42.5 years; 46 males) and two hundred ANX patients (average age 47.2 years; 17 males) participated. Neither polyenviromic risk score nor polyenviromic protective score differed significantly between PSYCH +MOOD and ANX groups (p = 0.149; p = 0.466, respectively). Scientific validity of the polyenviromic risk/protective score construct must still be demonstrated in large psychiatric samples, ideally in prospective studies. Nevertheless, researchers have already started to investigate environmental factors in the etiology of mental disorders in their complexity, similarly to polygenic risk scores.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30215 - Psychiatry

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Neuropsychiatric Disease and Treatment

ISSN

1176-6328

e-ISSN

1178-2021

Svazek periodika

21

Číslo periodika v rámci svazku

MAR

Stát vydavatele periodika

NZ - Nový Zéland

Počet stran výsledku

5

Strana od-do

541-545

Kód UT WoS článku

001678503400001

EID výsledku v databázi Scopus

2-s2.0-105000104480