Widened retinal arteriolar and venular diameters are not an endophenotype of schizophrenia: A one-time cross-sectional study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F23%3A73623492" target="_blank" >RIV/61989592:15110/23:73623492 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/67985904:_____/23:00581878 RIV/00216224:14310/23:00133104 RIV/61988987:17110/23:A2402M7Q RIV/00216208:11150/23:10468843 a 2 dalších

Výsledek na webu

<a href="https://www.nel.edu/userfiles/articlesnew/1695156375_44_5_hosak_290-pdf.pdf" target="_blank" >https://www.nel.edu/userfiles/articlesnew/1695156375_44_5_hosak_290-pdf.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Widened retinal arteriolar and venular diameters are not an endophenotype of schizophrenia: A one-time cross-sectional study

Popis výsledku v původním jazyce

Background: Both genetic and environmental factors are important in etiology of mental disorders. Calculating polyenviromic risk/ protective scores provides an updated perspective in research on the environmental causes of psychiatric disorders. We aimed to compare environmental risk and protective factors in patients with psychosis or a mood disorder (PSYCH+MOOD) and those with an anxiety disorder (ANX).Methods: We administered the internationally accepted questionnaire from the EUropean Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI) study, enriched with mood and anxiety disorder-relevant measures, to patients at two large university hospitals in the Czech Republic.Results: Ninety-four PSYCH+MOOD patients (average age 42.5 years; 46 males) and 52 ANX patients (average age 47.2 years; 17 males) participated. Neither polyenviromic risk score nor polyenviromic protective score differed significantly between PSYCH +MOOD and ANX groups (p = 0.149; p = 0.466, respectively).Conclusion: Scientific validity of the polyenviromic risk/protective score construct must still be demonstrated in large psychiatric samples, ideally in prospective studies. Nevertheless, researchers have already started to investigate environmental factors in the etiology of mental disorders in their complexity, similarly to polygenic risk scores.

Název v anglickém jazyce

Widened retinal arteriolar and venular diameters are not an endophenotype of schizophrenia: A one-time cross-sectional study

Popis výsledku anglicky

Background: Both genetic and environmental factors are important in etiology of mental disorders. Calculating polyenviromic risk/ protective scores provides an updated perspective in research on the environmental causes of psychiatric disorders. We aimed to compare environmental risk and protective factors in patients with psychosis or a mood disorder (PSYCH+MOOD) and those with an anxiety disorder (ANX).Methods: We administered the internationally accepted questionnaire from the EUropean Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI) study, enriched with mood and anxiety disorder-relevant measures, to patients at two large university hospitals in the Czech Republic.Results: Ninety-four PSYCH+MOOD patients (average age 42.5 years; 46 males) and 52 ANX patients (average age 47.2 years; 17 males) participated. Neither polyenviromic risk score nor polyenviromic protective score differed significantly between PSYCH +MOOD and ANX groups (p = 0.149; p = 0.466, respectively).Conclusion: Scientific validity of the polyenviromic risk/protective score construct must still be demonstrated in large psychiatric samples, ideally in prospective studies. Nevertheless, researchers have already started to investigate environmental factors in the etiology of mental disorders in their complexity, similarly to polygenic risk scores.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

30215 - Psychiatry

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

NEUROENDOCRINOLOGY LETTERS

ISSN

0172-780X

e-ISSN

2354-4716

Svazek periodika

44

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

SE - Švédské království

Počet stran výsledku

7

Strana od-do

290-296

Kód UT WoS článku

001101642500003

EID výsledku v databázi Scopus

999