The effects of RARa and RARa proteins on growth, viability, and differentiation of v-myb-transformed monoblasts

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F00%3A00000107" target="_blank" >RIV/00209805:_____/00:00000107 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The effects of RARa and RARa proteins on growth, viability, and differentiation of v-myb-transformed monoblasts

Popis výsledku v původním jazyce

We studied differentiation, proliferation, and death process in the cell line of v-myb-transformed monoblasts BM2 and their retinoic acid receptor (RAR) a- and retinoid X receptor (RXR) a-expressing derivatives after axposure to four different retinoids:all-trans retinoic acid, 9-cis retinoic acid, TTNPB, and LG1000153. The effects of retinoids on the phenotype of BM2, BM2RAR, and BM2RXR cells were correlated with the transcription activation function of the v-Myb oncoprotein of avian myeloblastosis virus. Our results suggest that ligand-activated RARa protein is primarily engaged in control of proliferation and differentiation of v-myb-transformed monoblasts, while activated RXRa protein controls their differentiation and death.

Název v anglickém jazyce

The effects of RARa and RARa proteins on growth, viability, and differentiation of v-myb-transformed monoblasts

Popis výsledku anglicky

We studied differentiation, proliferation, and death process in the cell line of v-myb-transformed monoblasts BM2 and their retinoic acid receptor (RAR) a- and retinoid X receptor (RXR) a-expressing derivatives after axposure to four different retinoids:all-trans retinoic acid, 9-cis retinoic acid, TTNPB, and LG1000153. The effects of retinoids on the phenotype of BM2, BM2RAR, and BM2RXR cells were correlated with the transcription activation function of the v-Myb oncoprotein of avian myeloblastosis virus. Our results suggest that ligand-activated RARa protein is primarily engaged in control of proliferation and differentiation of v-myb-transformed monoblasts, while activated RXRa protein controls their differentiation and death.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2000

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Blood Cells, Molecules, and Diseases

ISSN

1079-9796

e-ISSN

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Svazek periodika

26

Číslo periodika v rámci svazku

neuv.

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

12

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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