In vitro evaluation of the permeation of cytotoxic drugs through reconstructed human epidermis and oral epithelium

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F11%3A%230000197" target="_blank" >RIV/00209805:_____/11:#0000197 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.linkos.cz/files/klinicka-onkologie/162/3793.pdf" target="_blank" >http://www.linkos.cz/files/klinicka-onkologie/162/3793.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

In vitro evaluation of the permeation of cytotoxic drugs through reconstructed human epidermis and oral epithelium

Popis výsledku v původním jazyce

Backgrounds: Occupational exposure to antineoplastic agents may represent a risk to health care workers, although the relevance of different exposure routes is not fully understood. The objectives of this study were to determine in vitro permeation of four widely used cytotoxic drugs (cisplatin, cyclophosphamide, doxorubicin, and fluorouracil) through two reconstituted tissue models representing human skin epidermis and oral mucosa. Materials and Methods: Experiments were conducted with reconstructed models of human epidermis and oral epithelium, cultured in a chemically-defined medium under conditions simulating possible exposure scenarios (6 h duration, three concentrations corresponding to commonly used application doses). The amounts of drugs permeated through the tissues into the receptor media were determined using ultra performance liquid chromatography with photospectrometric detection. Results: The highest epidermis permeations (P = 0.2 x 10?3 ? 1.5 x 10?3 cm.h?1) were observe

Název v anglickém jazyce

In vitro evaluation of the permeation of cytotoxic drugs through reconstructed human epidermis and oral epithelium

Popis výsledku anglicky

Backgrounds: Occupational exposure to antineoplastic agents may represent a risk to health care workers, although the relevance of different exposure routes is not fully understood. The objectives of this study were to determine in vitro permeation of four widely used cytotoxic drugs (cisplatin, cyclophosphamide, doxorubicin, and fluorouracil) through two reconstituted tissue models representing human skin epidermis and oral mucosa. Materials and Methods: Experiments were conducted with reconstructed models of human epidermis and oral epithelium, cultured in a chemically-defined medium under conditions simulating possible exposure scenarios (6 h duration, three concentrations corresponding to commonly used application doses). The amounts of drugs permeated through the tissues into the receptor media were determined using ultra performance liquid chromatography with photospectrometric detection. Results: The highest epidermis permeations (P = 0.2 x 10?3 ? 1.5 x 10?3 cm.h?1) were observe

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

<a href="/cs/project/2B06171" target="_blank" >2B06171: Výzkum profesní zátěže zdravotnických pracovníků nakládajících s cytotoxickými léčivy v chronických prahových a podprahových expozicích.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Klinická onkologie

ISSN

0862-495X

e-ISSN

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Svazek periodika

24

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

8

Strana od-do

195-202

Kód UT WoS článku

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EID výsledku v databázi Scopus

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