Identification and characterisation of pro-metastatic targets, pathways and molecular complexes using a toolbox of proteomic technologies

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F12%3A%230000306" target="_blank" >RIV/00209805:_____/12:#0000306 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.linkos.cz/files/klinicka-onkologie/174/4135.pdf" target="_blank" >http://www.linkos.cz/files/klinicka-onkologie/174/4135.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Identification and characterisation of pro-metastatic targets, pathways and molecular complexes using a toolbox of proteomic technologies

Popis výsledku v původním jazyce

Background: Cancer metastasis involves changes in signalling pathways, cell adhesion, migration and invasiveness. Modern proteomic, mass spectrometry based techniques enable discovery of new pro-metastatic proteins and their functional partners. Also, they might be involved in their functional characterisation and validation towards development of new diagnostic and therapeutic approaches. Aim: The aim of this communication is to describe current possibilities for proteomic techniques in the discovery and characterisation of pro-metastatic targets. The NF-?B pathway is one of the players responsible for a number of pro-metastatic processes. The related proteins can be discovered using untargeted proteomic approaches by comparing proteomes with different metastatic potential. Stable isotope labelling based methods enable a parallel analysis of more tumour samples. The identified pro-metastatic proteins can be characterised in relationship to cell migration, invasiveness and proliferatio

Název v anglickém jazyce

Identification and characterisation of pro-metastatic targets, pathways and molecular complexes using a toolbox of proteomic technologies

Popis výsledku anglicky

Background: Cancer metastasis involves changes in signalling pathways, cell adhesion, migration and invasiveness. Modern proteomic, mass spectrometry based techniques enable discovery of new pro-metastatic proteins and their functional partners. Also, they might be involved in their functional characterisation and validation towards development of new diagnostic and therapeutic approaches. Aim: The aim of this communication is to describe current possibilities for proteomic techniques in the discovery and characterisation of pro-metastatic targets. The NF-?B pathway is one of the players responsible for a number of pro-metastatic processes. The related proteins can be discovered using untargeted proteomic approaches by comparing proteomes with different metastatic potential. Stable isotope labelling based methods enable a parallel analysis of more tumour samples. The identified pro-metastatic proteins can be characterised in relationship to cell migration, invasiveness and proliferatio

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Klinická onkologie

ISSN

0862-495X

e-ISSN

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Svazek periodika

25

Číslo periodika v rámci svazku

supplementum 2

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

8

Strana od-do

"2S70"-"2S77"

Kód UT WoS článku

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EID výsledku v databázi Scopus

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