Initial experience with determination of hTERC and MYCC amplification in cervical intraepithelial neoplasia and cervical carcinoma in the Czech Republi
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F12%3A%230000380" target="_blank" >RIV/00209805:_____/12:#0000380 - isvavai.cz</a>
Výsledek na webu
<a href="http://www.touchoncology.com/articles/initial-experience-determination-hterc-and-mycc-amplification-cervical-intraepithelial-neop" target="_blank" >http://www.touchoncology.com/articles/initial-experience-determination-hterc-and-mycc-amplification-cervical-intraepithelial-neop</a>
DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Initial experience with determination of hTERC and MYCC amplification in cervical intraepithelial neoplasia and cervical carcinoma in the Czech Republi
Popis výsledku v původním jazyce
Tumours are frequently characterised by series of cytogenetic abnormalities. Amplifications of the human telomerase gene hTERC (3q26) and myelocytomatosis-C proto-oncogene MYCC (8q24) have been associated with cervical intraepithelial neoplasia (CIN) andcarcinoma of the uterine cervix. The results of genetic analysis allow to select patients at high risk of progression from CIN to carcinoma. Our group conducted a study in which the chromosomal abnormalities found in the cytology specimens of 26 patients with either cervical cancer or CIN were analysed using the recently developed triple-colour human papillomavirus-fluorescence in situ hybridisation (HPV-FISH) assay. HPV infection was proven in 22 (85 %) patients. Amplification of MYCC and hTERC was found in 11 (42 %) and 16 (62 %) patients, respectively. Based on these results, the patients were divided into high-risk, medium-risk and low-risk groups. The study confirmed that the HPV-FISH assay can be used as an effective diagnostic p
Název v anglickém jazyce
Initial experience with determination of hTERC and MYCC amplification in cervical intraepithelial neoplasia and cervical carcinoma in the Czech Republi
Popis výsledku anglicky
Tumours are frequently characterised by series of cytogenetic abnormalities. Amplifications of the human telomerase gene hTERC (3q26) and myelocytomatosis-C proto-oncogene MYCC (8q24) have been associated with cervical intraepithelial neoplasia (CIN) andcarcinoma of the uterine cervix. The results of genetic analysis allow to select patients at high risk of progression from CIN to carcinoma. Our group conducted a study in which the chromosomal abnormalities found in the cytology specimens of 26 patients with either cervical cancer or CIN were analysed using the recently developed triple-colour human papillomavirus-fluorescence in situ hybridisation (HPV-FISH) assay. HPV infection was proven in 22 (85 %) patients. Amplification of MYCC and hTERC was found in 11 (42 %) and 16 (62 %) patients, respectively. Based on these results, the patients were divided into high-risk, medium-risk and low-risk groups. The study confirmed that the HPV-FISH assay can be used as an effective diagnostic p
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FD - Onkologie a hematologie
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
Z - Vyzkumny zamer (s odkazem do CEZ)
Ostatní
Rok uplatnění
2012
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
European oncology and haematology
ISSN
2045-5275
e-ISSN
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Svazek periodika
8
Číslo periodika v rámci svazku
2
Stát vydavatele periodika
GB - Spojené království Velké Británie a Severního Irska
Počet stran výsledku
5
Strana od-do
92-96
Kód UT WoS článku
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EID výsledku v databázi Scopus
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