A mini review of organometallic compounds and their anticancer properties

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F13%3A%230000442" target="_blank" >RIV/00209805:_____/13:#0000442 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.mzm.cz/fileadmin/user_upload/publikace/casopisy/fm_49_2_2013/fm-2-2013-abstract-05.pdf" target="_blank" >http://www.mzm.cz/fileadmin/user_upload/publikace/casopisy/fm_49_2_2013/fm-2-2013-abstract-05.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

A mini review of organometallic compounds and their anticancer properties

Popis výsledku v původním jazyce

Chemistry of organometallic compounds is a rapidly developing research area. In comparison with purely organic compounds, organometallic compounds show unique chemical properties including structural diversity, variety of available interactions, possibility of ligand exchange and redox and catalytic properties that can be used for medical purposes. The discovery of antitumor properties of cisplatin in 1979 by Rosenberg and its introduction to oncology brought a lot of interest in metal complexes chemistry containing other transition metals. Regardless of severe side-effects and frequent development of tumor resistance, cisplatin, oxaliplatin and carboplatin are still the most successful anticancer compounds. Nevertheless, it is essential to search fornovel anticancer drugs with different modes of action, better selectivity and less side-effects. Organometallic compounds represent a new opportunity to achieve this goal.

Název v anglickém jazyce

A mini review of organometallic compounds and their anticancer properties

Popis výsledku anglicky

Chemistry of organometallic compounds is a rapidly developing research area. In comparison with purely organic compounds, organometallic compounds show unique chemical properties including structural diversity, variety of available interactions, possibility of ligand exchange and redox and catalytic properties that can be used for medical purposes. The discovery of antitumor properties of cisplatin in 1979 by Rosenberg and its introduction to oncology brought a lot of interest in metal complexes chemistry containing other transition metals. Regardless of severe side-effects and frequent development of tumor resistance, cisplatin, oxaliplatin and carboplatin are still the most successful anticancer compounds. Nevertheless, it is essential to search fornovel anticancer drugs with different modes of action, better selectivity and less side-effects. Organometallic compounds represent a new opportunity to achieve this goal.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

<a href="/cs/project/ED2.1.00%2F03.0101" target="_blank" >ED2.1.00/03.0101: Regionální centrum aplikované molekulární onkologie (RECAMO)</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Folia Mendeliana

ISSN

0085-0748

e-ISSN

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Svazek periodika

49

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

5

Strana od-do

53-57

Kód UT WoS článku

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EID výsledku v databázi Scopus

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