Titanocenes as anticancer agents: recent insights

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F17%3A00077873" target="_blank" >RIV/00209805:_____/17:00077873 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.eurekaselect.com/148762/article" target="_blank" >http://www.eurekaselect.com/148762/article</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2174/1573406412666161228113650" target="_blank" >10.2174/1573406412666161228113650</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Titanocenes as anticancer agents: recent insights

Popis výsledku v původním jazyce

Enormous success of antitumor agent cisplatin initiated interest in other organometallic complexes. A subclass of organometallic compounds termed metallocenes, characterized by a transition metal central atom (M) bound to cyclopentadienide (Cp-/[C5H5]-) ligands with the basic formula Cp2M, has gained increasing interest as promising anticancer agents. This review is aimed at a progress in the development of organometallic titanium-based compounds focusing primarily on the evaluation of their cytotoxic activity and mechanism of action in relation to potential utilization as anticancer drugs. Metallocenes bearing titanium as central atom were sorted according to their structure and modifications and their anticancer activity is further discussed. Titanocenes represent family of promising compounds exerting cytostatic activity. We suggest that their application not only as separate agents, but also in combination with newly developed carriers, e.g. nanomaterials, may lead to improvement of their delivery into tumor cells and following utilization in cancer treatment.

Název v anglickém jazyce

Titanocenes as anticancer agents: recent insights

Popis výsledku anglicky

Enormous success of antitumor agent cisplatin initiated interest in other organometallic complexes. A subclass of organometallic compounds termed metallocenes, characterized by a transition metal central atom (M) bound to cyclopentadienide (Cp-/[C5H5]-) ligands with the basic formula Cp2M, has gained increasing interest as promising anticancer agents. This review is aimed at a progress in the development of organometallic titanium-based compounds focusing primarily on the evaluation of their cytotoxic activity and mechanism of action in relation to potential utilization as anticancer drugs. Metallocenes bearing titanium as central atom were sorted according to their structure and modifications and their anticancer activity is further discussed. Titanocenes represent family of promising compounds exerting cytostatic activity. We suggest that their application not only as separate agents, but also in combination with newly developed carriers, e.g. nanomaterials, may lead to improvement of their delivery into tumor cells and following utilization in cancer treatment.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30204 - Oncology

Projekt

<a href="/cs/project/LO1413" target="_blank" >LO1413: RECAMO2020</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Medicinal chemistry

ISSN

1573-4064

e-ISSN

—

Svazek periodika

13

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

AE - Spojené arabské emiráty

Počet stran výsledku

11

Strana od-do

334-344

Kód UT WoS článku

000402479000003

EID výsledku v databázi Scopus

2-s2.0-85020793064