Circulating 25-Hydroxyvitamin D-3 and Survival after Diagnosis with Kidney Cancer

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F15%3A00078752" target="_blank" >RIV/00209805:_____/15:00078752 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/15:10297528 RIV/61989592:15110/15:33154945

Výsledek na webu

<a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC4526455/" target="_blank" >https://pmc.ncbi.nlm.nih.gov/articles/PMC4526455/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1158/1055-9965.EPI-14-1351" target="_blank" >10.1158/1055-9965.EPI-14-1351</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Circulating 25-Hydroxyvitamin D-3 and Survival after Diagnosis with Kidney Cancer

Popis výsledku v původním jazyce

Prospective cohort studies have provided some evidence that circulating vitamin D is associated with risk of, and survival from, renal cell carcinoma (RCC), but it is unclear whether concentrations of vitamin D at the time of diagnosis of RCC are associated with prognosis. We conducted a case-cohort study of 630 RCC cases, including 203 deaths, from a multicenter case-control study in Eastern Europe. Vitamin D was assessed as 25-hydroxyvitamin D-3 [25(OH)D-3], and we used weighted Cox models to estimate hazard ratios (HR) and 95% confidence intervals (CI) by categories of season-adjusted 25(OH)D-3. Higher concentrations of 25(OH)D-3 were associated with lower risk of death after adjusting for stage, age, sex, and country (HR highest vs. lowest category 0.57; 95% CI, 0.34-0.97). The inverse associations of 25(OH)D-3 with death were most notable among those who died from non-RCC causes and those diagnosed with early-stage disease. In summary, 25(OH)D-3 concentration at diagnosis of RCC was inversely associated with all-cause mortality rates, but not specifically with RCC outcome. (C) 2015 AACR.

Název v anglickém jazyce

Circulating 25-Hydroxyvitamin D-3 and Survival after Diagnosis with Kidney Cancer

Popis výsledku anglicky

Prospective cohort studies have provided some evidence that circulating vitamin D is associated with risk of, and survival from, renal cell carcinoma (RCC), but it is unclear whether concentrations of vitamin D at the time of diagnosis of RCC are associated with prognosis. We conducted a case-cohort study of 630 RCC cases, including 203 deaths, from a multicenter case-control study in Eastern Europe. Vitamin D was assessed as 25-hydroxyvitamin D-3 [25(OH)D-3], and we used weighted Cox models to estimate hazard ratios (HR) and 95% confidence intervals (CI) by categories of season-adjusted 25(OH)D-3. Higher concentrations of 25(OH)D-3 were associated with lower risk of death after adjusting for stage, age, sex, and country (HR highest vs. lowest category 0.57; 95% CI, 0.34-0.97). The inverse associations of 25(OH)D-3 with death were most notable among those who died from non-RCC causes and those diagnosed with early-stage disease. In summary, 25(OH)D-3 concentration at diagnosis of RCC was inversely associated with all-cause mortality rates, but not specifically with RCC outcome. (C) 2015 AACR.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30204 - Oncology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Cancer epidemiology, biomarkers &amp; prevention

ISSN

1055-9965

e-ISSN

1538-7755

Svazek periodika

24

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

5

Strana od-do

1277-1281

Kód UT WoS článku

000359320500018

EID výsledku v databázi Scopus

2-s2.0-84941775696