Circulating 25-Hydroxyvitamin D-3 and Survival after Diagnosis with Kidney Cancer

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10297528" target="_blank" >RIV/00216208:11110/15:10297528 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15110/15:33154945

Výsledek na webu

<a href="http://dx.doi.org/10.1158/1055-9965.EPI-14-1351" target="_blank" >http://dx.doi.org/10.1158/1055-9965.EPI-14-1351</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1158/1055-9965.EPI-14-1351" target="_blank" >10.1158/1055-9965.EPI-14-1351</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Circulating 25-Hydroxyvitamin D-3 and Survival after Diagnosis with Kidney Cancer

Popis výsledku v původním jazyce

Prospective cohort studies have provided some evidence that circulating vitamin D is associated with risk of, and survival from, renal cell carcinoma (RCC), but it is unclear whether concentrations of vitamin D at the time of diagnosis of RCC are associated with prognosis. We conducted a case-cohort study of 630 RCC cases, including 203 deaths, from a multicenter case-control study in Eastern Europe. Vitamin D was assessed as 25-hydroxyvitamin D-3 [25(OH)D-3], and we used weighted Cox models to estimatehazard ratios (HR) and 95% confidence intervals (CI) by categories of season-adjusted 25(OH)D-3. Higher concentrations of 25(OH)D-3 were associated with lower risk of death after adjusting for stage, age, sex, and country (HR highest vs. lowest category0.57; 95% CI, 0.34-0.97). The inverse associations of 25(OH)D-3 with death were most notable among those who died from non-RCC causes and those diagnosed with early-stage disease. In summary, 25(OH)D-3 concentration at diagnosis of RCC w

Název v anglickém jazyce

Circulating 25-Hydroxyvitamin D-3 and Survival after Diagnosis with Kidney Cancer

Popis výsledku anglicky

Prospective cohort studies have provided some evidence that circulating vitamin D is associated with risk of, and survival from, renal cell carcinoma (RCC), but it is unclear whether concentrations of vitamin D at the time of diagnosis of RCC are associated with prognosis. We conducted a case-cohort study of 630 RCC cases, including 203 deaths, from a multicenter case-control study in Eastern Europe. Vitamin D was assessed as 25-hydroxyvitamin D-3 [25(OH)D-3], and we used weighted Cox models to estimatehazard ratios (HR) and 95% confidence intervals (CI) by categories of season-adjusted 25(OH)D-3. Higher concentrations of 25(OH)D-3 were associated with lower risk of death after adjusting for stage, age, sex, and country (HR highest vs. lowest category0.57; 95% CI, 0.34-0.97). The inverse associations of 25(OH)D-3 with death were most notable among those who died from non-RCC causes and those diagnosed with early-stage disease. In summary, 25(OH)D-3 concentration at diagnosis of RCC w

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

—

Projekt

<a href="/cs/project/7E11062" target="_blank" >7E11062: Cancer Genomics of the Kidney</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Cancer Epidemiology Biomarkers and Prevention

ISSN

1055-9965

e-ISSN

—

Svazek periodika

24

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

5

Strana od-do

1277-1281

Kód UT WoS článku

000359320500018

EID výsledku v databázi Scopus

2-s2.0-84941775696